Nanoscale Structural Mapping of Protein Aggregates in Live Cells Modeling Huntington's Disease
Z. Guo, G. Chiesa, J. Yin, A. Sanford, S. J. Meier, A. S. Khalil, J.-X. Cheng
This paper uses MIP microscopy to map the nanoscale secondary structure of huntingtin protein aggregates in live yeast cells, revealing a β-sheet core and α-helix shell, and shows prion-dependent structural differences.
bioRxiv · Oct 9, 2023 · PreprintBiophysics