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10 papers
Recent·Most cited
Z. Guo, G. Chiesa, J. Yin, A. Sanford, S. J. Meier, A. S. Khalil, J.-X. Cheng
This paper uses MIP microscopy to map the nanoscale secondary structure of huntingtin protein aggregates in live yeast cells, revealing a β-sheet core and α-helix shell, and shows prion-dependent structural differences.
bioRxiv · Oct 9, 2023 · PreprintBiophysics
D. Garcia-Ruano, A. Jain, Z. J. Heins, B. G. Wong, E. Y. Wolle, A. S. Khalil, D. Coudreuse
The paper upgrades the eVOLVER platform to enable long-term, automated experimental evolution of proliferating cells with improved methodology, hardware, and software.
bioRxiv · Mar 28, 2023Evolutionary Biology
I. Sutradhar, C. Ching, D. Desai, Z. Heins, A. S. Khalil, M. H. Zaman
This study investigates how antibiotic interactions in wastewater affect antimicrobial resistance development in E. coli, finding that synergistic interactions suppress resistance while antagonistic interactions show ratio-dependent resistance development.
bioRxiv · Feb 10, 2023Bioengineering
M. Friesen, A. S. Khalil, M. I. Barrasa, J. F. Jeppesen, D. Mooney, R. Jaenisch
This paper develops a protocol to generate human pluripotent stem cell-derived adipocytes that respond to physiological insulin levels and model insulin resistance in diabetes.
bioRxiv · Feb 22, 2022Cell Biology
I. Sutradhar, C. Ching, D. Desai, M. Suprenant, E. Briars, Z. Heins, A. S. Khalil, M. H. Zaman
The paper develops a computational model to predict antibiotic resistant bacteria growth in wastewater, finding horizontal gene transfer and antibiotic interactions drive resistance more than chromosomal mutations.
bioRxiv · Oct 9, 2020Bioengineering
C. P. Mancuso, H. Lee, C. I. Abreu, J. Gore, A. S. Khalil
The paper investigates how environmental disturbances affect microbial community diversity by decomposing disturbances into intensity and fluctuation components and observing their effects on soil-derived bacterial communities.
bioRxiv · Jul 28, 2020Bioengineering
J. Qian, Z.-x. Lu, C. P. Mancuso, H.-Y. Jhuang, R. d. C. Barajas-Ornelas, S. Boswell, F. H. Ramirez-Guadiana, V. Jones, A. Sonti, K. Sedlack, L. Artzi, G. Jung, M. Arammash, M. Melfi, L. Lyon, , M. Springer
This paper develops a synthetic microbial spore system for high-resolution object provenance tracking with rapid decoding and biocontainment.
bioRxiv · Mar 14, 2020 · PreprintBioengineering
Y. Ding, P. R. Weckwerth, E. Poretsky, K. M. Murphy, J. Sims, E. Saldivar, S. A. Christensen, S. N. Char, B. Yang, A.-d. Tong, Z. Shen, K. Kremling, E. S. Buckler, T. J. Y. Kono, D. R. Nelson, , A. Huffaker
The paper identifies ten genes in maize that drive antibiotic biosynthesis, revealing a resilient pathway critical for disease resistance.
bioRxiv · Mar 4, 2020 · PreprintPlant Biology
Q. Sun, N. M. Vega, B. Cervantes, C. Mancuso, N. Mao, M. N. Taylor, J. J. Collins, A. S. Khalil, J. Gore, T. K. Lu
This study shows that introducing cellulolytic bacteria into C. elegans allows the host to utilize cellulose as a carbon source, improving nutrition and larval yield.
bioRxiv · Mar 1, 2020 · PreprintMicrobiology
J. Krakowiak, X. Zheng, N. Patel, J. Anandhakumar, K. Valerius, D. S. Gross, A. S. Khalil, D. Pincus
The paper validates a mathematical model of the yeast heat shock response by showing Hsp70-mediated negative feedback regulates Hsf1 activity through specific binding sites and domains.
bioRxiv · Aug 31, 2017Biochemistry