Probing the mechanism of Cbl-b inhibition by a small-molecule inhibitor
S. Kimani, S. Perveen, M. Szewczyk, H. Zeng, A. Dong, F. Li, P. Ghiabi, Y. Li, I. Chau, C. Arrowsmith, D. Barsyte-Lovejoy, V. Santhakumar, M. Vedadi, L. Halabelian
The paper investigates how a small-molecule inhibitor binds to and inactivates Cbl-b, revealing a structural mechanism that locks the protein in an inactive conformation.
bioRxiv · May 5, 2023 · PreprintImmunology