Author

S. Kriaucionis

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Biophysics· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Organism:human· 4 Approach:statistical model· 4 Research Focus:chromatin & epigenetic regulation· 2 Assay:ATAC-seq· 1 Assay:bulk RNA-seq· 1 Assay:DNA methylation· 1 Research Focus:drug response / drug discovery· 1 Assay:scRNA-seq· 1

Frequent Co-Authors

A. K. Gandhi· 1 shared A. Smith· 1 shared B. Bou-Tayeh· 1 shared B. Schuster-Boeckler· 1 shared B. Usukhbayar· 1 shared C. Zhou· 1 shared C.-X. Song· 1 shared D. Petkeviciute-Gerlach· 1 shared

Activity by Year

2017-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 12 mutual co-author links

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1 shared paperCancer Biology

A. K. Gandhi

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4 papers

Recent·Most cited

Nucleosome wrapping energy in CpG islands and the role of epigenetic base modifications

R. Giniunaite, R. Sharma, J. H. Maddocks, S. Kriaucionis, D. Petkeviciute-Gerlach

The paper models how CpG island density and epigenetic modifications affect DNA nucleosome wrapping energy and probability.

bioRxiv · Apr 6, 2024Biophysics

UXS1 regulates UDP-GlcA levels to support growth of UGDH-high cancer cells

Y. Wang, C. Zhou, B. Bou-Tayeh, R. Lisle, S. Kriaucionis, Y. Shi

The paper identifies UXS1 as a selectively essential gene in UGDH-high cancer cells, showing it regulates UDP-GlcA levels to prevent toxicity and highlights it as a therapeutic target.

bioRxiv · Feb 8, 2024 · PreprintCell Biology

Dysregulation of chromatin via H3K27 methylation underpins differentiation arrest in Isocitrate dehydrogenase-mutant Acute Myeloid Leukaemia.

D. R. Silveira, P. Chatzikyriakou, P. Casares Alaez, S. Mackie, R. Hulks, O. Yavorska, P. Siejka-Zielinska, A. Smith, M. Metzner, B. Usukhbayar, V. Penard-Lacronique, C.-X. Song, A. K. Gandhi, P. Vyas, T. Milne, , L. Quek

This study shows that IDH2 mutations in AML block differentiation by altering H3K27 methylation, and that Enasidenib can reverse this block by modulating chromatin states.

bioRxiv · Aug 24, 2023 · PreprintCancer Biology

Widespread impact of DNA replication on mutational mechanisms in cancer

M. Tomkova, J. Tomek, S. Kriaucionis, B. Schuster-Boeckler

The paper quantifies how DNA replication timing and direction influence mutational signatures across 19 cancer types, finding that 22 out of 29 signatures are significantly affected.

bioRxiv · Aug 19, 2017Cancer Biology