Author

S. Kumar Bharathkar

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:mouse· 2 Assay:proteomics· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Research Focus:clustering· 1 Assay:cryo-EM· 1

Frequent Co-Authors

B. M. Stadtmueller· 2 shared A. Malyutin· 1 shared B. Stadtmueller· 1 shared B. W. Parker· 1 shared E. Tajkhorshid· 1 shared K. E. Huey-Tubman· 1 shared M. J. Miller· 1 shared N. Haloi· 1 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

8 top collaborators · 16 mutual co-author links

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2 shared papersImmunology

B. M. Stadtmueller

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3 papers

Recent·Most cited

Structural and biochemical requirements for secretory component interactions with dimeric Immunoglobulin A

S. Kumar Bharathkar, B. M. Stadtmueller

This study identifies key residues in secretory component domains D1 and D3 and JC C-terminal residues that mediate binding to dIgA and stabilize SIgA structure.

bioRxiv · Nov 9, 2023 · PreprintImmunology

Engineered Secretory Immunoglobulin A provides insights on antibody-based effector mechanisms targeting Clostridiodes difficile

S. Kumar Bharathkar, M. J. Miller, B. M. Stadtmueller

This study engineers chimeric SIgA to investigate and enhance effector mechanisms against C. difficile, showing increased neutralization and bacterial clumping.

bioRxiv · Nov 8, 2023 · PreprintImmunology

The Structures of Secretory and Dimeric Immunoglobulin A

S. Kumar Bharathkar, B. W. Parker, A. Malyutin, N. Haloi, K. E. Huey-Tubman, E. Tajkhorshid, B. Stadtmueller

This study reports the cryo-EM structures of murine secretory and dimeric IgA, revealing their conformational features and interactions with the secretory component.

bioRxiv · Feb 16, 2020Immunology