The actin nucleator Spir-1 is a virus restriction factor that promotes IRF3 activation
A. A. Torres, S. L. Macilwee, A. Rashid, S. E. Cox, J. D. Albarnaz, C. A. Bonjardim, G. L. Smith
This paper identifies Spir-1 as a virus restriction factor that enhances IRF3 activation in response to RNA viruses and is targeted by the viral protein K7 to suppress antiviral responses.
bioRxiv · Aug 31, 2020Microbiology