Single-cell analysis of patient-derived PDAC organoids reveals cell state heterogeneity and a conserved developmental hierarchy
T. G. Krieger, S. LeBlanc-Soto, J. Jabs, F. W. Ten, N. Ishaque, K. Jechow, O. Debnath, C.-S. Leonhardt, A. Giri, R. Eils, O. Strobel, C. Conrad
The paper uses single-cell RNA sequencing to analyze PDAC organoids and identifies conserved cell states and a differentiation hierarchy linked to tumor subtypes.
bioRxiv · Aug 23, 2020Cancer Biology