Author

S. Lek

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Biology Disciplines

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Evolutionary Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 1 Organism:E. coli· 1 Approach:statistical model· 1 Assay:whole-genome sequencing· 1

Frequent Co-Authors

A. Anderson· 1 shared A. M. Hujer· 1 shared C. Bryant· 1 shared D. Nichol· 1 shared J. Rutter· 1 shared J. Scott· 1 shared M. D. Adams· 1 shared P. Jeavons· 1 shared

Activity by Year

2019-2019 · peak 1/yr

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9 top collaborators · 36 mutual co-author links

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1 shared paperEvolutionary Biology

A. Anderson

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1 paper

Recent·Most cited

Antibiotic collateral sensitivity is contingent on the repeatability of evolution

D. Nichol, J. Rutter, C. Bryant, A. M. Hujer, S. Lek, M. D. Adams, P. Jeavons, A. Anderson, R. Bonomo, J. Scott

This study shows that sequential antibiotic treatments may overestimate therapeutic benefits due to stochastic resistance or susceptibility outcomes in E. coli.

bioRxiv · Jan 9, 2019Evolutionary Biology