Author

C. Bryant

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 2 Biochemistry· 1 Cancer Biology· 1 Ecology· 1 Evolutionary Biology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:drug response / drug discovery· 3 Research Focus:cell type annotation· 2 Organism:human· 2 Approach:statistical model· 2 Organism:bacteria (other)· 1 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1

Frequent Co-Authors

A. Anderson· 1 shared A. B. Nicotra· 1 shared A. Eason· 1 shared A. Gallardo-Godoy· 1 shared A. Herms· 1 shared A. M. Hujer· 1 shared A. Midson· 1 shared A. Mondal· 1 shared

Activity by Year

2019-2023 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 8 mutual co-author links

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1 shared paperEvolutionary Biology

A. Anderson

Mutual co-authors in cluster

Author profile →

7 papers

Recent·Most cited

Elevation-dependent patterns of snow-gum dieback are moderated by trait differences between montane and subalpine forests.

C. Bryant, M. C. Ball, J. O. Borevitz, M. T. Brookhouse, H. Carle, P. Cunningham, M. Davey, J. Davies, A. Eason, J. D. Erskine, T. I. Fuenzalida, D. Grishin, R. Harris, J. Kriticos, A. Midson, , H. Bothwell

The paper examines elevation-dependent patterns of snow-gum dieback and finds trait differences between montane and subalpine subspecies influence borer-damage severity.

bioRxiv · Dec 4, 2023 · PreprintEcology

Development of covalent chemogenetic K2P channel activators

P. E. Deal, H. Lee, A. Mondal, M. Lolicato, P. R. Furtado de Mandonca, H. Black, X. El-Hilali, C. Bryant, E. Y. Isacoff, A. Renslo, D. L. Minor

This paper develops a chemogenetic method to irreversibly activate K2P channels, enabling studies of their function and potential therapeutic applications.

bioRxiv · Oct 15, 2023Biophysics

The delayed kinetics of Myddosome formation explains why Aβ aggregates trigger TLR4 less efficiently than LPS

B. Li, P. Suresh, J. Brelstaff, S. Kedia, C. Bryant, D. Klenerman

This study shows that Aβ aggregates trigger TLR4 less efficiently than LPS due to slower Myddosome formation and longer lifetimes of larger Myddosomes.

bioRxiv · Sep 28, 2023Biophysics

Architectural asymmetry enables DNA transport through the Helicobacter pylori cag type IV secretion system

M. E. Ryan, P. P. Damke, C. Bryant, M. J. Sheedlo, C. L. Shaffer

The paper shows architectural asymmetry in the Helicobacter pylori cag T4SS enables DNA translocation while allowing protein and peptidoglycan effector transport.

bioRxiv · Jul 25, 2023 · PreprintMicrobiology

Levelling out differences in aerobic glycolysis neutralizes the competitive advantage of oncogenic PIK3CA mutant progenitors in the esophagus

A. Herms, B. Colom, G. Piedrafita, K. Murai, S. H. Ong, D. Fernandez-Antoran, C. Bryant, C. Frezza, B. Vanhaesebroeck, P. H. Jones

The paper shows that reducing aerobic glycolysis differences between mutant and wild-type cells limits the competitive advantage of PIK3CA mutant progenitors in the esophagus.

bioRxiv · May 28, 2021Cancer Biology

Small molecule inhibitors of a human recombination-associated ATPase, RAD54

K. T. Ehmsen, K. K. H. Ang, W. D. Wright, J. L. Davies, Y. Younis, Y. Birman, C. Bryant, A. Gallardo-Godoy, A. R. Renslo, R. J. Neitz, M. R. Arkin, W.-D. Heyer

This study identifies small molecule inhibitors of the human RAD54 ATPase, which is involved in homologous recombination, and evaluates their effects on DNA repair and cancer cell survival.

bioRxiv · Apr 19, 2019 · PreprintBiochemistry

Antibiotic collateral sensitivity is contingent on the repeatability of evolution

D. Nichol, J. Rutter, C. Bryant, A. M. Hujer, S. Lek, M. D. Adams, P. Jeavons, A. Anderson, R. Bonomo, J. Scott

This study shows that sequential antibiotic treatments may overestimate therapeutic benefits due to stochastic resistance or susceptibility outcomes in E. coli.

bioRxiv · Jan 9, 2019Evolutionary Biology