Author

A. M. Hujer

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 2 Evolutionary Biology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:deep learning· 2 Research Focus:protein folding & dynamics· 2 Approach:statistical model· 2 Organism:bacteria (other)· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:drug response / drug discovery· 1 Organism:E. coli· 1 Approach:mechanistic / dynamical model· 1

Frequent Co-Authors

R. A. Bonomo· 3 shared S. Haider· 3 shared J. Gu· 2 shared S. Chen· 2 shared A. Anderson· 1 shared A. R. Mack· 1 shared A. W. E. Chan· 1 shared C. Bethel· 1 shared

Activity by Year

2019-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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3 shared papersBiophysics

R. A. Bonomo

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Author profile →

4 papers

Recent·Most cited

{Omega}-Loop mutations control dynamics of the active site by modulating the hydrogen-bonding network in PDC-3 β-lactamase

S. Chen, A. R. Mack, A. M. Hujer, C. R. Bethel, R. A. Bonomo, S. Haider

This study investigates how {Omega}-loop mutations in PDC-3 β-lactamase affect its active site dynamics and catalytic activity through molecular simulations.

eLife · Jan 21, 2026Peer-reviewedBiophysics

Deciphering the co-evolutionary dynamics of L2 β-lactamases via Deep learning

Y. Zhu, J. Gu, Z. Zhao, A. W. E. Chan, M. F. Mojica, A. M. Hujer, R. A. Bonomo, S. Haider

This paper uses deep learning to analyze the co-evolutionary dynamics of L2 β-lactamases and their functional mechanisms.

bioRxiv · Jan 14, 2024 · PreprintMicrobiology

The Structural Role of N170 in Substrate-assisted Deacylation in KPC-2 β-Lactamase

D. Parwana, J. Gu, S. Chen, C. Bethel, E. K. Marshall, A. M. Hujer, R. A. Bonomo, S. Haider

This study investigates the structural role of N170 in substrate-assisted deacylation in KPC-2 β-lactamase, revealing its impact on drug binding and catalytic activity.

bioRxiv · May 22, 2023Biophysics

Antibiotic collateral sensitivity is contingent on the repeatability of evolution

D. Nichol, J. Rutter, C. Bryant, A. M. Hujer, S. Lek, M. D. Adams, P. Jeavons, A. Anderson, R. Bonomo, J. Scott

This study shows that sequential antibiotic treatments may overestimate therapeutic benefits due to stochastic resistance or susceptibility outcomes in E. coli.

bioRxiv · Jan 9, 2019Evolutionary Biology