A testosterone metabolite 19-hydroxyandrostenedione induces neuroendocrine trans-differentiation of prostate cancer cells via an ectopic olfactory receptor
T. Abaffy, J. R. Bain, M. J. Muehlbauer, I. Spasojevic, S. Lodha, E. Bruguera, S. K. Neal, S. Y. Kim, H. Matsunami
This study identifies 19-hydroxyandrostenedione as an endogenous agonist of OR51E2 that induces neuroendocrine trans-differentiation in prostate cancer cells.
bioRxiv · Jan 4, 2018Cancer Biology