Author

H. Matsunami

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 2 Biochemistry· 1 Cancer Biology· 1 Evolutionary Biology· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 5 Approach:experimental assay· 5 Research Focus:differential expression· 4 Organism:human· 4 Assay:bulk RNA-seq· 3 Organism:mouse· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell-cell communication· 1

Frequent Co-Authors

C. A. de March· 4 shared E. Bruguera· 2 shared N. Vaidehi· 2 shared A. Manglik· 1 shared A. Mescher· 1 shared A. Purk· 1 shared B. Faust· 1 shared C. B. Billesboelle· 1 shared

Activity by Year

2018-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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4 shared papersCell Biology

C. A. de March

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Author profile →

6 papers

Recent·Most cited

Genetic and functional odorant receptor variation in the Homo lineage

C. A. de March, H. Matsunami, M. Abe, M. Cobb, K. C. C. Hoover

The paper uses ancient DNA to study olfactory receptor variation in Homo, finding conserved structures in relatives but functional differences in H. sapiens that may expand adaptive capacity.

iScience · Jan 1, 2023Peer-reviewedEvolutionary Biology

Structural basis of odorant recognition by a human odorant receptor

C. B. Billesboelle, C. A. de March, W. J. C. van der Velden, N. Ma, J. Tewari, C. Linas del Torrent, L. Li, B. Faust, N. Vaidehi, H. Matsunami, A. Manglik

The paper determines the structure of a human odorant receptor bound to propionate, revealing how odorant recognition and activation occur through specific molecular interactions.

bioRxiv · Dec 20, 2022 · PreprintBiochemistry

Modulation of the combinatorial code of odorant receptor response patterns in odorant mixtures

C. A. de March, W. B. Titlow, T. Sengoku, P. Breheny, H. Matsunami, T. S. McClintock

The paper identifies OR response patterns to odorants and mixtures in mice, showing common interactions that explain olfactory phenomena.

bioRxiv · Jan 15, 2020Cell Biology

Structural instability and divergence from conserved residues underlie intracellular retention of mammalian odorant receptors

K. Ikegami, C. A. de March, M. Nagai, S. Ghosh, M. Do, R. Sharma, E. Bruguera, Y. Lu, Y. Fukutani, N. Vaidehi, M. Yohda, H. Matsunami

This study identifies structural instability and divergence from conserved residues as causes of intracellular retention of odorant receptors, using computational and experimental methods.

bioRxiv · Dec 4, 2019Cell Biology

Beta-caryophyllene enhances wound healing through multiple routes.

S. Koyama, A. Purk, M. Kaur, H. A. Soini, M. V. Novotny, K. Davis, C. C. Kao, H. Matsunami, A. Mescher

This study shows beta-caryophyllene enhances wound healing in mice by promoting cell proliferation, migration, and stem cell activity, with sex-specific effects.

bioRxiv · Nov 20, 2019Physiology

A testosterone metabolite 19-hydroxyandrostenedione induces neuroendocrine trans-differentiation of prostate cancer cells via an ectopic olfactory receptor

T. Abaffy, J. R. Bain, M. J. Muehlbauer, I. Spasojevic, S. Lodha, E. Bruguera, S. K. Neal, S. Y. Kim, H. Matsunami

This study identifies 19-hydroxyandrostenedione as an endogenous agonist of OR51E2 that induces neuroendocrine trans-differentiation in prostate cancer cells.

bioRxiv · Jan 4, 2018Cancer Biology