S. Y. Kim

In-situ microscopy-assisted meniscus-guided coating for highly sensitive reduced graphene oxide-based nanocomposite biosensor

The paper develops a meniscus-guided coating technique using in-situ microscopy and CFD modeling to create high-performance rGO-based biosensors with picomolar detection limits.

Recommendations For a Standardized Approach to Histopathologic Evaluation of Synovial Membrane in Murine Models of Experimental Osteoarthritis

The paper develops a standardized histopathologic evaluation approach for synovial membrane in murine OA models, showing good inter-reader agreement and consistent findings across stains.

Physiologic Doses of TGF-beta Improve the Composition of Engineered Articular Cartilage

The paper investigates the effect of physiologic TGF-beta doses on engineered cartilage composition, finding that lower doses improve neocartilage properties compared to supraphysiologic doses.

A synthetic lethal screen for Snail-induced enzalutamide resistance identifies JAK/STAT signaling as a therapeutic vulnerability in prostate cancer

The paper identifies JAK/STAT signaling as a therapeutic target for Snail-induced enzalutamide-resistant prostate cancer through synthetic lethal screens and validation in a resistant cell model.

Phage DNA polymerase prevents deleterious on-target damage and enhances precise CRISPR/Cas9 editing

This study identifies T4 DNA polymerase as a tool to enhance CRISPR/Cas9 editing precision by reducing on-target deletions and translocations while increasing insertion accuracy.

Choline metabolism underpins macrophage IL-4 polarization and RELMα up-regulation in helminth infection

This study shows that choline metabolism is essential for IL-4-induced macrophage polarization and RELMα expression during helminth infection, affecting immune homeostasis and parasite clearance.

Selection against admixture and gene regulatory divergence in a long-term primate field study

The paper combines field observations and genomic data from baboons to study admixture and gene regulatory divergence, finding selection against introgression similar to archaic hominins.

Pleural macrophages translocate to the lung during infection to promote improved influenza outcomes

This study identifies pleural macrophages migrating to the lung during influenza infection, which correlates with improved disease outcomes.

Structural-guided fragment-based drug discovery applied to antitoxin, MAB3862 opens a new possibility of exploring the Toxin and Antitoxin for antibiotics.

The paper explores using toxin-antitoxin complexes as a novel drug target through fragment-based drug discovery, identifying MAB3862 as an antitoxin and demonstrating a strategy for inhibitor design.

Non-Covalently Associated Streptavidin Multi-Arm Nanohubs Exhibit Mechanical and Thermal Stability in Protein-Network Materials

This study characterizes non-covalently associated streptavidin nanohubs as stable protein-network materials with properties similar to chemically bonded hydrogels.

Interleukin-10 knockout mice do not reliably exhibit macroscopic inflammation: a natural history endoscopic surveillance study

This study tracks endoscopic changes in IL-10 knockout mice and finds that 40% do not develop colitis, with all cases resolving spontaneously.

The genetic basis of tail-loss evolution in humans and apes

This paper identifies an Alu element insertion in the TBXT gene as the genetic mechanism driving tail-loss evolution in hominoids, showing it causes alternative splicing and tail absence in mice.

Visualizing cancer-originated acetate uptake through MCT1 in reactive astrocytes demarcates tumor border and extends survival in glioblastoma patients

This study uses AcePET to visualize tumor boundaries and reactive astrocytes in GBM, showing that targeting MCT1 improves survival by enabling complete resection of cancer stem cells.

The Arabidopsis ORA59 coordinates jasmonic acid- and ethylene-responsive gene expression to regulate plant immunity

This study identifies ERELEE4 as an ORA59-binding cis-element and shows ORA59 regulates JA/ET-responsive genes through direct promoter binding, with differential preference for GCC box and ERELEE4 based on hormone activation.

A cross-species drug discovery pipeline to identify and validate new treatments for osteosarcoma

This study develops a cross-species drug discovery pipeline to identify and validate new treatments for osteosarcoma, finding that dual inhibition of proteasome and CRM1 pathways induces synergistic cytotoxicity.

Effects of sustained inflation pressure during neonatal cardiopulmonary resuscitation of asphyxiated piglets

This study examines the effect of different peak inflation pressures during sustained inflation in neonatal resuscitation of asphyxiated piglets, finding similar time to ROSC but increased inflammation with higher pressure.

Glycosaminoglycan binding motif at S1/S2 proteolytic cleavage site on spike glycoprotein may facilitate novel coronavirus (SARS-CoV-2) host cell entry

This study identifies a glycosaminoglycan-binding motif in SARS-CoV-2 spike glycoprotein that enhances binding to heparin, suggesting a role in host cell entry and potential for carbohydrate-based therapies.

Orthogonal genome-wide screenings in bat cells identify MTHFD1 as a target of broad antiviral therapy

The paper identifies MTHFD1 as a target for broad antiviral therapy by screening bat cells with RNAi and CRISPR libraries against mumps and influenza viruses.

A stealth adhesion factor contributes to Vibrio vulnificus pathogenicity: Flp pili play roles in host invasion, survival in the blood stream and resistance to complement activation

This study shows that all three Tad operons in Vibrio vulnificus are required for pathogenicity, as they enable host invasion, survival in blood, and resistance to complement activation through Flp pili.

Widespread transcriptional scanning in the testis modulates gene evolution rates

The paper maps gene expression in human spermatogenesis and finds that expressed genes have fewer germline mutations, suggesting transcriptional scanning reduces DNA damage and influences gene evolution rates.

From the clinic to the bench and back again in one dog year: identifying new treatments for sarcoma using a cross-species personalized medicine pipeline

This paper develops a cross-species personalized medicine pipeline using canine sarcomas to identify new treatments, finding proteasome inhibitors initially effective but limited by tumor heterogeneity.

An integrative systems biology and experimental approach identifies convergence of epithelial plasticity, metabolism, and autophagy to promote chemoresistance

A testosterone metabolite 19-hydroxyandrostenedione induces neuroendocrine trans-differentiation of prostate cancer cells via an ectopic olfactory receptor

This study identifies 19-hydroxyandrostenedione as an endogenous agonist of OR51E2 that induces neuroendocrine trans-differentiation in prostate cancer cells.