Mammary Tissue-Derived Extracellular Matrix Hydrogels Reveal the Role of Irradiation in Driving a Pro-Tumor and Immunosuppressive Microenvironment
T. Zhu, S. M. Alves, A. Adamo, X. Wen, K. C. Corn, A. Shostak, S. Johnson, N. D. Shaub, S. E. Martello, B. C. Hacker, A. D'Amore, R. Bardhan, M. Rafat
This study shows that irradiated mammary tissue ECM hydrogels promote TNBC cell proliferation, invasion, and immunosuppression by altering ECM composition and macrophage polarization.
bioRxiv · May 16, 2022Cancer Biology