Author

M. Rafat

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 7 Biochemistry· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 7 Organism:mouse· 6 Research Focus:cancer & tumor microenvironment· 4 Research Focus:cell type annotation· 3 Research Focus:cell-cell communication· 2 Research Focus:differential expression· 2 Research Focus:host-pathogen & immune response· 2 Organism:human· 2

Frequent Co-Authors

S. E. Martello· 4 shared B. C. Hacker· 3 shared E. E. Graves· 3 shared K. C. Corn· 3 shared A. Shostak· 2 shared E. J. Lin· 2 shared R. von Eyben· 2 shared T. Zhu· 2 shared

Activity by Year

2019-2024 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 22 mutual co-author links

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4 shared papersCancer Biology

S. E. Martello

Mutual co-authors in cluster

Author profile →

8 papers

Recent·Most cited

miR-100 and miR-125b Contribute to Enhanced 3D Growth and Invasiveness and can be Functionally Transferred to Silence Target Genes in Recipient Cells

H. M. Nelson, S. Qu, L. Huang, M. Shameer, K. C. Corn, S. N. Chapman, N. L. Luthcke, S. A. Schuster, L. A. Turnbull, L. L. Guy, X. Liu, K. C. Vickers, Q. Liu, J. L. Franklin, A. Weaver, , J. G. Patton

This study identifies miR-100 and miR-125b as regulators of 3D growth and invasiveness in cancer cells, showing they can be transferred extracellularly to silence target genes in recipient cells.

bioRxiv · Jan 16, 2024 · PreprintCancer Biology

Ultrafast Power Doppler Ultrasound Enables Longitudinal Tracking of Vascular Changes that Correlate with Immune Response After Radiotherapy

S. E. Martello, J. Xia, J. Kusunose, B. C. Hacker, M. A. Mayeaux, E. J. Lin, A. Hawkes, A. Singh, C. F. Caskey, M. Rafat

This paper uses ultrafast power Doppler ultrasound to track vascular changes in tumors after radiotherapy, showing correlation with immune response.

bioRxiv · Aug 4, 2023Cancer Biology

Irradiated Mammary Spheroids Elucidate Mechanisms of Macrophage-Mediated Breast Cancer Recurrence

B. C. Hacker, D. C. Herman, E. J. Lin, A. M. Questell, S. E. Martello, R. J. Hedges, A. J. Walker, M. Rafat

The paper develops a spheroid model to study macrophage-mediated breast cancer recurrence and identifies IL-6 signaling as a key mechanism.

bioRxiv · Jul 24, 2022Cancer Biology

Radiation-Induced Autophagy Regulates the Fibroblast Mitochondrial Stress Response and Crosstalk with Triple-Negative Breast Cancer Cells

K. C. Corn, S. E. Martello, V. K. Menon, L. S. Britto, K. K. Simmons, Y. K. Mohamed, Y. I. Ivanova, A. A. Ghelmansaraei, S. A. Weidenbach, T. Zhu, E. Krystofiak, J. D. Young, V. Gama, M. Rafat

This study shows that radiation-induced autophagy in fibroblasts alters their mitochondrial stress response, promoting an aggressive phenotype in triple-negative breast cancer cells.

bioRxiv · May 17, 2022Cancer Biology

Mammary Tissue-Derived Extracellular Matrix Hydrogels Reveal the Role of Irradiation in Driving a Pro-Tumor and Immunosuppressive Microenvironment

T. Zhu, S. M. Alves, A. Adamo, X. Wen, K. C. Corn, A. Shostak, S. Johnson, N. D. Shaub, S. E. Martello, B. C. Hacker, A. D'Amore, R. Bardhan, M. Rafat

This study shows that irradiated mammary tissue ECM hydrogels promote TNBC cell proliferation, invasion, and immunosuppression by altering ECM composition and macrophage polarization.

bioRxiv · May 16, 2022Cancer Biology

Non-Invasive monitoring of normal tissue radiation damage using quantitative ultrasound spectroscopy

M. Rafat, A. El Kaffas, A. Swarnakar, A. Shostak, E. E. Graves

This study uses quantitative ultrasound spectroscopy to monitor radiation-induced changes in normal tissue and correlates findings with histological features.

bioRxiv · May 10, 2022Cancer Biology

FLASH irradiation enhances the therapeutic index of abdominal radiotherapy for the treatment of ovarian cancer

K. Levy, S. Natarajan, J. Wang, S. Chow, J. T. Eggold, P. Loo, R. Manjappa, F. M. Lartey, E. Schüler, L. Skinner, M. Rafat, R. Ko, A. Kim, D. Al Rawi, R. von Eyben, , E. B. Rankin

This study shows FLASH irradiation reduces intestinal injury while maintaining ovarian cancer treatment efficacy in preclinical models.

bioRxiv · Dec 12, 2019 · PreprintCancer Biology

Extracellular 2’3’-cGAMP is an immunotransmitter produced by cancer cells and regulated by ENPP1

J. A. Carozza, V. Boehnert, K. C. Nguyen, G. Skariah, K. E. Shaw, J. A. Brown, M. Rafat, R. von Eyben, E. E. Graves, J. S. Glenn, M. Smith, L. Li

The paper identifies extracellular 2’3’-cGAMP as an immunotransmitter released by cancer cells, regulated by ENPP1, and shows its therapeutic potential in tumor treatment.

bioRxiv · Oct 7, 2019Biochemistry