Exposure to nitric oxide drives transition to differential culturability in Mycobacterium tuberculosis
S. M. Glenn, B. Gap-Gaupool, E. Milburn, O. Turapov, M. Crosatti, J. Hincks, B. Stewart, J. Bacon, S. L. Kendall, M. I. Voskuil, O. Riabova, N. Monakhova, J. Green, S. J. Waddell, V. Makarov, G. V. Mukamolova
This study shows that nitric oxide exposure leads to the formation of Rpf-dependent differentially culturable Mycobacterium tuberculosis subpopulations, which are resistant to standard diagnostics and treatments.
bioRxiv · Sep 28, 2021 · PreprintMicrobiology