Author

S. J. Waddell

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 3 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:host-pathogen & immune response· 3 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Assay:ChIP-seq· 1 Research Focus:differential expression· 1 Organism:human· 1 Organism:mouse· 1

Frequent Co-Authors

G. V. Mukamolova· 2 shared J. Bacon· 2 shared M. I. Voskuil· 2 shared O. Turapov· 2 shared A. A. Witney· 1 shared A. B. Lanne· 1 shared A. d. Visch· 1 shared A. Feula· 1 shared

Activity by Year

2019-2021 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 23 mutual co-author links

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Curved chords = mutual co-authorship

2 shared papersMicrobiology

G. V. Mukamolova

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Exposure to nitric oxide drives transition to differential culturability in Mycobacterium tuberculosis

S. M. Glenn, B. Gap-Gaupool, E. Milburn, O. Turapov, M. Crosatti, J. Hincks, B. Stewart, J. Bacon, S. L. Kendall, M. I. Voskuil, O. Riabova, N. Monakhova, J. Green, S. J. Waddell, V. Makarov, G. V. Mukamolova

This study shows that nitric oxide exposure leads to the formation of Rpf-dependent differentially culturable Mycobacterium tuberculosis subpopulations, which are resistant to standard diagnostics and treatments.

bioRxiv · Sep 28, 2021 · PreprintMicrobiology

Azetidines kill Mycobacterium tuberculosis without detectable resistance by blocking mycolate assembly.

A. B. Lanne, Y. Cui, E. Browne, P. G. E. Craven, N. J. Cundy, N. J. Coltman, K. Dale, A. Feula, J. Frampton, A. Goff, M. A. Hama Salih, X. Lang, X. Li, C. W. Moon, M. Morton, , L. J. Alderwick

The paper identifies azetidine derivatives that kill Mycobacterium tuberculosis without resistance by inhibiting mycolate assembly, showing a novel mode of action and favorable pharmacological profiles.

bioRxiv · Sep 3, 2020 · PreprintMicrobiology

Elevated LRRK2 and α-synuclein levels in CSF of infectious meningitis patients

S. Herbst, S. Marais, M. G. Gutierrez, S. J. Waddell, R. J. Wilkinson, R. P. Lai

The paper finds elevated levels of LRRK2 and α-synuclein in CSF of infectious meningitis patients, suggesting a link between neuroinflammation and infection.

bioRxiv · Apr 4, 2019 · PreprintImmunology

Protein kinase B controls Mycobacterium tuberculosis growth via phosphorylation of the global transcriptional regulator Lsr2

K. Alqaseer, O. Turapov, P. Barthe, H. Jagatia, A. d. Visch, C. Roumestand, M. Wegrzyn, I. L. Bartek, M. I. Voskuil, H. O'Hare, A. A. Witney, M. Cohen-Gonsaud, S. J. Waddell, G. V. Mukamolova

This study shows that PknB phosphorylates Lsr2, affecting its DNA binding and M. tuberculosis growth under hypoxia.

bioRxiv · Mar 8, 2019Microbiology