J. Green

Diploid gametes in maize by mutation of A-Type cyclins: a step towards apomeiosis and synthetic apomixis.

This study shows that mutating maize A-type cyclin genes leads to diploid gametes and tetraploid progeny, advancing synthetic apomixis in maize.

A tale of too many trees: a conundrum for phylogenetic regression

This paper investigates the consequences of gene tree-species tree mismatch in phylogenetic regression and finds high false positive rates when trees are mismatched.

Early-life exposures to specific commensal microbes prevent type 1 diabetes.

A defined consortium of early-life microbes shapes immune development and prevents type 1 diabetes.

Atlas-Guided Discovery of Transcription Factors for T Cell Programming

The paper identifies transcription factors driving distinct CD8+ T cell states and shows their impact on tumor control and immunotherapy.

New high-resolution maps show that rubber causes significant deforestation

The paper uses satellite data to show rubber expansion caused more deforestation in Southeast Asia than previously estimated, highlighting the need for updated policies.

Modulation of adaptive immune responses by Akkermansia muciniphila is restricted to an early life window in NOD mice

This study shows Akkermansia muciniphila induces regulatory T cells and enhances antibody responses in NOD mice only when exposed before weaning, highlighting a critical early-life window for immune modulation.

3D Visualisation of trans-syncytial nanopores provides a pathway for paracellular diffusion across the human placental syncytiotrophoblast

The paper identifies trans-syncytial nanopores in the placental syncytiotrophoblast as pathways for paracellular diffusion, supported by 3D visualization and mathematical modeling.

Arresting microbiome development limits immune system maturation and resistance to infection.

This study shows that delaying microbiome development during weaning impairs immune system maturation and increases susceptibility to infection.

Exposure to nitric oxide drives transition to differential culturability in Mycobacterium tuberculosis

This study shows that nitric oxide exposure leads to the formation of Rpf-dependent differentially culturable Mycobacterium tuberculosis subpopulations, which are resistant to standard diagnostics and treatments.

NLRP3 activation in response to disrupted endocytic traffic

This study shows NLRP3 detects disrupted endosome trafficking, leading to inflammasome activation and cytokine release in macrophages.

Cytomegaloviral determinants of CD8+ T cell programming and RhCMV/SIV vaccine efficacy

This study identifies eight genes in two RhCMV regions that control unconventional CD8+ T cell responses and vaccine efficacy against SIV challenge.

Mycobacterium smegmatis expands across surfaces using hydraulic sliding

This paper identifies a new form of bacterial motility in Mycobacterium smegmatis called hydraulic sliding, where colony expansion occurs through liquid core expansion rather than cell growth.

Pretreatment of aged mice with retinoic acid restores alveolar regeneration via upregulation of reciprocal PDGFRA signaling

This study shows that pretreatment with retinoic acid in aged mice enhances alveolar regeneration by increasing PDGFA signaling, which supports fibroblast activation and epithelial cell differentiation.

Pre-winter fattening and fat loss during wing moult: the annual cycle of fat deposition in captive barnacle geese (branta leucopsis)

This study investigates fat deposition and loss in captive barnacle geese during wing moult and pre-winter fattening, finding significant fat reduction during moult and peak fat storage in late-September to early-October.

Mechanics Of Flight Feathers: Effects Of Captivity?

The paper compares flight feather stiffness and size between wild and captive Barnacle Geese and feathers dropped versus regrown during moult, finding wild feathers are stiffer despite long-distance migration.

Biomarker-guided treatment strategies for ovarian cancer identified from a heterogeneous panel of patient-derived tumor xenografts

This study identifies biomarker-guided treatment strategies for ovarian cancer using patient-derived tumor xenografts, finding that nearly 90% of PDXs responded to at least one targeted therapy.

Near-chromosome level genome assembly of the fruit pest Drosophila suzukii using long-read sequencing

This paper improves the genome assembly of Drosophila suzukii using long-read sequencing, resulting in a higher quality and more contiguous genome compared to previous short-read assemblies.

Quantitative assessment of fecal contamination in multiple environmental sample types in urban communities in Dhaka, Bangladesh using SaniPath microbial approach

The paper assesses fecal contamination in urban Dhaka using E. coli MPN measurements across different environmental samples and finds higher contamination in low-income areas compared to high-income and transient neighborhoods.

Folic acid prevents C. elegans folate deficiency indirectly via bacterial uptake of a breakdown product: a route that can also increase bacterial toxicity and ageing

This study shows folic acid prevents C. elegans folate deficiency indirectly by being taken up by E. coli via AbgT, which can also increase bacterial toxicity and ageing.