Cryo-EM Structures of HIV-1 trimer bound to CD4-mimetics M48U1 and BNM-III-170 adopt a CD4-bound open conformation
C. A. Jette, C. O. Barnes, S. M. Kirk, B. Melillo, A. B. Smith, P. J. Bjorkman
The paper presents cryo-EM structures of HIV-1 Env trimers bound to CD4-mimetics, showing conformational changes induced by Phe43 pocket binding.
bioRxiv · Aug 21, 2020Biochemistry