C. O. Barnes

Discovery and engineering of the antibody response against a prominent skin commensal

The paper identifies an antibody response against Staphylococcus epidermidis and shows how it can be engineered for therapeutic vaccination.

Structural basis of transcription: RNA Polymerase II substrate binding and metal coordination at 3.0 A using a free-electron laser

This paper presents the structure of ATP-bound RNA Polymerase II at 3.0 Å resolution using a free-electron laser, revealing new insights into substrate binding and metal coordination in the active site.

Human anti-ACE2 monoclonal antibodies as pan-sarbecovirus prophylactic agents

The paper develops human monoclonal antibodies targeting the ACE2 receptor to block infection by SARS-CoV-2 and related sarbecoviruses, showing broad efficacy against variants and no adverse effects on ACE2 function.

HIV-1 CD4-binding site germline antibody-Env structures inform vaccine design

The paper uses cryo-EM to study germline antibody-Env structures to identify key interactions and guide vaccine design.

A naturally arising broad and potent CD4-binding site antibody with low somatic mutation

This paper describes a VRC01-class antibody with lower somatic mutation but comparable breadth and potency to other broadly neutralizing antibodies against HIV-1.

Conserved Neutralizing Epitopes on the N-Terminal Domain of Variant SARS-CoV-2 Spike Proteins

The paper identifies conserved neutralizing epitopes on the N-terminal domain of SARS-CoV-2 spike proteins using NTD-specific probes and characterizes antibodies that neutralize multiple variants.

Rapid Identification of Neutralizing Antibodies against SARS-CoV-2 Variants by mRNA Display

This study uses mRNA display to identify and engineer neutralizing antibodies against SARS-CoV-2 variants, revealing binding modes and demonstrating their effectiveness against mutations in the spike protein.

Naturally enhanced neutralizing breadth to SARS-CoV-2 after one year

This study shows that convalescent individuals with or without vaccination maintain neutralizing activity and memory B cells against SARS-CoV-2 for up to one year, with vaccination enhancing breadth and potency against variants.

Broad cross-reactivity across sarbecoviruses exhibited by a subset of COVID-19 donor-derived neutralizing antibodies

The paper identifies two class 4 anti-RBD antibodies from COVID-19 donors that broadly neutralize zoonotic sarbecoviruses and SARS-CoV-2 variants with high potency.

Mutational escape from the polyclonal antibody response to SARS-CoV-2 infection is largely shaped by a single class of antibodies

The paper maps mutations in SARS-CoV-2 spike RBD that escape binding by three antibody classes and finds that plasma escape maps closely resemble those of a single antibody class targeting site E484.

mRNA vaccine-elicited antibodies to SARS-CoV-2 and circulating variants

This study examines antibody and memory B cell responses to mRNA vaccines against SARS-CoV-2 and assesses their effectiveness against emerging variants.

Bispecific antibody neutralizes circulating SARS-CoV-2 variants, prevents escape and protects mice from disease

Mosaic nanoparticles elicit cross-reactive immune responses to zoonotic coronaviruses in mice

The paper demonstrates that mosaic nanoparticles displaying multiple coronavirus RBDs induce cross-reactive and neutralizing antibodies against SARS-CoV-2 and zoonotic coronaviruses in mice.

Evolution of Antibody Immunity to SARS-CoV-2

This study examines the evolution of antibody immunity to SARS-CoV-2 over time, finding that memory B cells evolve with increased potency and resistance to mutations.

Cryo-EM Structures of HIV-1 trimer bound to CD4-mimetics M48U1 and BNM-III-170 adopt a CD4-bound open conformation

The paper presents cryo-EM structures of HIV-1 Env trimers bound to CD4-mimetics, showing conformational changes induced by Phe43 pocket binding.

A Broadly Neutralizing Macaque Monoclonal Antibody Against the HIV-1 V3-Glycan Patch

This paper reports a broadly neutralizing monoclonal antibody from a macaque infected with SHIVAD8 that targets the V3-glycan patch of HIV-1 Env, showing neutralizing activity and protective efficacy in vivo.

Structures of human antibodies bound to SARS-CoV-2 spike reveal common epitopes and recurrent features of antibodies

Molecular mimicry in deoxy-nucleotide catalysis: the structure of Escherichia coli dGTPase reveals the molecular basis of dGTP selectivity

This paper determines the structure of Escherichia coli dGTPase and elucidates the molecular basis of its dGTP selectivity through comparative analysis with SAMHD1.