P. J. Bjorkman

Variant mutation in SARS-CoV-2 nucleocapsid enhances viral infection via altered genomic encapsidation

The paper identifies a mutation in the SARS-CoV-2 nucleocapsid protein that enhances viral infection by promoting dimer formation and altering virion structure.

Designed mosaic nanoparticles enhance cross-reactive immune responses in mice

The paper designs mosaic nanoparticles with SARS-like betacoronavirus RBDs to enhance cross-reactive immune responses in mice, finding that mosaic-7COM elicits stronger responses against zoonotic sarbecoviruses and Omicrons.

Mosaic sarbecovirus nanoparticles elicit cross-reactive responses in pre-vaccinated animals

The paper shows mosaic-8b nanoparticles induce broader cross-reactive antibodies than homotypic ones, even in pre-vaccinated animals, suggesting potential for improved vaccine design against emerging sarbecoviruses.

Protein design for evaluating vaccines against future viral variation

The paper designs SARS-CoV-2 Spike proteins with novel mutations to evaluate vaccine effectiveness against future viral variants using a deep learning model.

Multiviral Quartet Nanocages Elicit Broad Anti-Coronavirus Responses for Proactive Vaccinology

A vaccine candidate with polyprotein antigens displayed on nanocages induces neutralizing antibodies to multiple SARS-like coronaviruses.

ESCRT recruitment to mRNA-encoded SARS-CoV-2 spike induces virus-like particles and enhanced antibody responses

This study develops a vaccine technology using mRNA encoding spike-EABR to generate eVLPs, enhancing antibody and T-cell responses against SARS-CoV-2 variants.

CD4-binding site immunogens elicit heterologous anti-HIV-1 neutralizing antibodies in transgenic and wildtype animals

This study shows that CD4bs immunogens can elicit potent, broad anti-HIV-1 neutralizing antibodies in transgenic and wildtype animals.

Timeline of changes in spike conformational dynamics in emergent SARS-CoV-2 variants reveal progressive stabilization of trimer stalk and enhanced NTD dynamics

The paper tracks changes in SARS-CoV-2 spike protein dynamics across variants using hydrogen/deuterium exchange mass spectrometry, revealing progressive stabilization of the trimer stalk and enhanced NTD dynamics in Omicron BA.1.

Antibody recognition of CD4-induced open HIV-1 Env trimers

This paper characterizes monoclonal antibodies that recognize the CD4-induced open conformation of HIV-1 Env trimers and describes their structural interactions with Env and CD4.

Neutralizing monoclonal antibodies elicited by mosaic RBD nanoparticles bind conserved sarbecovirus epitopes

This study identifies cross-reactive monoclonal antibodies against conserved sarbecovirus epitopes using mosaic RBD nanoparticles and shows their neutralization potential against SARS-CoV-2 variants and animal sarbecoviruses.

Mosaic RBD nanoparticles protect against multiple sarbecovirus challenges in animal models

This study designs mosaic RBD nanoparticles to elicit antibodies against conserved sarbecovirus epitopes, showing broader protection against SARS-CoV-2 variants and animal sarbecoviruses in animal models.

HIV-1 CD4-binding site germline antibody-Env structures inform vaccine design

The paper uses cryo-EM to study germline antibody-Env structures to identify key interactions and guide vaccine design.

A naturally arising broad and potent CD4-binding site antibody with low somatic mutation

This paper describes a VRC01-class antibody with lower somatic mutation but comparable breadth and potency to other broadly neutralizing antibodies against HIV-1.

Neutralizing antibodies induced in immunized macaques recognize the CD4-binding site on an occluded-open HIV-1 envelope trimer

This study identifies two antibodies from immunized macaques that neutralize HIV-1 by targeting the CD4-binding site on an occluded-open Env trimer conformation.

Antibody elicited by HIV-1 immunogen vaccination in macaques displaces Env fusion peptide and destroys a neutralizing epitope

This study identifies an off-target antibody that displaces the HIV-1 Env fusion peptide and blocks neutralizing epitopes, providing insights for vaccine design.

Mutational escape from the polyclonal antibody response to SARS-CoV-2 infection is largely shaped by a single class of antibodies

The paper maps mutations in SARS-CoV-2 spike RBD that escape binding by three antibody classes and finds that plasma escape maps closely resemble those of a single antibody class targeting site E484.

mRNA vaccine-elicited antibodies to SARS-CoV-2 and circulating variants

This study examines antibody and memory B cell responses to mRNA vaccines against SARS-CoV-2 and assesses their effectiveness against emerging variants.

The evolution of interdependence in a four-way mealybug symbiosis

This paper studies the genomic and metabolic interdependence of two recently acquired gammaproteobacterial endosymbionts in mealybugs, showing their rapid adaptation to an intracellular lifestyle.

Bispecific antibody neutralizes circulating SARS-CoV-2 variants, prevents escape and protects mice from disease

In vitro characterization of engineered red blood cells as potent viral traps against HIV-1 and SARS-CoV-2

This study engineers red blood cells to express viral receptors, demonstrating their ability to neutralize HIV-1 and SARS-CoV-2 in vitro.

Mosaic nanoparticles elicit cross-reactive immune responses to zoonotic coronaviruses in mice

The paper demonstrates that mosaic nanoparticles displaying multiple coronavirus RBDs induce cross-reactive and neutralizing antibodies against SARS-CoV-2 and zoonotic coronaviruses in mice.

Evolution of Antibody Immunity to SARS-CoV-2

This study examines the evolution of antibody immunity to SARS-CoV-2 over time, finding that memory B cells evolve with increased potency and resistance to mutations.

Cryo-EM Structures of HIV-1 trimer bound to CD4-mimetics M48U1 and BNM-III-170 adopt a CD4-bound open conformation

The paper presents cryo-EM structures of HIV-1 Env trimers bound to CD4-mimetics, showing conformational changes induced by Phe43 pocket binding.

A Broadly Neutralizing Macaque Monoclonal Antibody Against the HIV-1 V3-Glycan Patch

This paper reports a broadly neutralizing monoclonal antibody from a macaque infected with SHIVAD8 that targets the V3-glycan patch of HIV-1 Env, showing neutralizing activity and protective efficacy in vivo.

Structures of human antibodies bound to SARS-CoV-2 spike reveal common epitopes and recurrent features of antibodies

Electron tomography visualization of HIV-1 fusion with target cells using fusion inhibitors to trap the pre-hairpin intermediate

The paper uses fusion inhibitors to trap HIV-1 in a pre-hairpin intermediate state and visualizes it via electron tomography, revealing the structure of Env-mediated fusion.

A Combination of Two Human Monoclonal Antibodies Limits Fetal Damage by Zika Virus in Macaques

This study shows that two Fc-modified monoclonal antibodies limit fetal neurologic damage and vertical transmission of ZIKV in pregnant macaques.

Construction, characterization, and immunization of nanoparticles that display a diverse array of influenza HA trimers

This study constructs and characterizes influenza HA trimer-displaying nanoparticles and evaluates their immunogenicity, finding that mosaic particles do not consistently elicit broader immune responses than homotypic ones.

Harnessing Avidity: Quantifying Entropic and Energetic Effects of Linker Length and Rigidity Required for Multivalent Binding of Antibodies to HIV-1 Spikes

This paper models synthetic diFabs with DNA linkers to quantify how linker length and rigidity affect antibody neutralization potency against HIV-1.

LEM2 recruits CHMP7 for ESCRT-mediated nuclear envelope closure in fission yeast and human cells

This study identifies LEM2 and CHMP7 as conserved factors that recruit ESCRT-III proteins to the nuclear envelope during closure in fission yeast and human cells.