Author

C. A. Jette

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Cancer Biology· 1 Immunology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:host-pathogen & immune response· 2 Organism:human· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Assay:cryo-EM· 1 Research Focus:drug response / drug discovery· 1 Organism:mouse· 1

Frequent Co-Authors

A. A. Cohen· 2 shared A. P. West· 2 shared C. O. Barnes· 2 shared J. R. Keeffe· 2 shared P. J. Bjorkman· 2 shared P. N. P. Gnanapragasam· 2 shared Y. E. Lee· 2 shared A. B. Smith· 1 shared

Activity by Year

2020-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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2 shared papersMicrobiology

A. A. Cohen

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

A Simple and Scalable Zebrafish Model of Sonic Hedgehog Medulloblastoma

M. J. Casey, P. P. Chan, Q. Li, C. A. Jette, M. Kohler, B. R. Myers, R. A. Stewart

This paper develops a zebrafish model of Sonic Hedgehog medulloblastoma by mutating ptch1 and identifies grk3 as a target for tumor formation.

bioRxiv · Feb 3, 2024Cancer Biology

Mosaic RBD nanoparticles protect against multiple sarbecovirus challenges in animal models

A. A. Cohen, N. A. van Doremalen, A. J. Greaney, H. Andersen, A. Sharma, T. N. Starr, J. R. Keeffe, C. Fan, J. E. Schulz, P. N. P. Gnanapragasam, L. M. Kakutani, A. P. West, G. Saturday, Y. E. Lee, H. Gao, , P. J. Bjorkman

This study designs mosaic RBD nanoparticles to elicit antibodies against conserved sarbecovirus epitopes, showing broader protection against SARS-CoV-2 variants and animal sarbecoviruses in animal models.

bioRxiv · Mar 25, 2022 · PreprintMicrobiology

Broad cross-reactivity across sarbecoviruses exhibited by a subset of COVID-19 donor-derived neutralizing antibodies

C. A. Jette, A. A. Cohen, P. N. P. Gnanapragasam, F. Muecksch, Y. E. Lee, K. E. Huey-Tubman, F. Schmidt, T. Hatziioannou, P. D. Bieniasz, M. C. Nussenzweig, A. P. West, J. R. Keeffe, P. Bjorkman, C. O. Barnes

The paper identifies two class 4 anti-RBD antibodies from COVID-19 donors that broadly neutralize zoonotic sarbecoviruses and SARS-CoV-2 variants with high potency.

bioRxiv · Apr 23, 2021Immunology

Cryo-EM Structures of HIV-1 trimer bound to CD4-mimetics M48U1 and BNM-III-170 adopt a CD4-bound open conformation

C. A. Jette, C. O. Barnes, S. M. Kirk, B. Melillo, A. B. Smith, P. J. Bjorkman

The paper presents cryo-EM structures of HIV-1 Env trimers bound to CD4-mimetics, showing conformational changes induced by Phe43 pocket binding.

bioRxiv · Aug 21, 2020Biochemistry