Stepwise design of pseudosymmetric protein hetero-oligomers
R. D. Kibler, S. Lee, M. A. Kennedy, B. I. M. Wicky, S. M. Lai, M. M. Kostelic, X. Li, C. M. Chow, L. Carter, V. H. Wysocki, B. L. Stoddard, D. Baker
The paper introduces a method to design pseudosymmetric protein hetero-oligomers by redesigning symmetric homo-oligomers and recombining them to form new hetero-oligomers with high structural specificity.
bioRxiv · Apr 7, 2023 · PreprintBiochemistry