L. Carter

De novo design of buttressed loops for sculpting protein functions

This paper designs proteins with structured loops supported by hydrogen bonds, demonstrating their stability and functionality in binding extended peptides.

Saponin Nanoparticle Adjuvants Incorporating Toll-Like Receptor Agonists Drive Distinct Immune Signatures and Potent Vaccine Responses

This paper develops a modular saponin-based nanoparticle adjuvant platform incorporating TLR agonists, showing improved vaccine potency and breadth against COVID-19 and HIV in mice.

Depletion of lamins B1 and B2 alters chromatin mobility and induces differential gene expression by a mesoscale-motion dependent mechanism

This study shows that depleting lamins B1 and B2 changes chromatin mobility and gene expression through mesoscale-motion dependent mechanisms.

De novo design of highly selective miniprotein inhibitors of integrins αvβ6 and αvβ8

This paper designs highly selective miniprotein inhibitors for integrins αvβ6 and αvβ8 with picomolar affinity and therapeutic potential in a mouse fibrosis model.

Antigen spacing on protein nanoparticles influences antibody responses to vaccination

This study shows that antigen spacing on protein nanoparticles affects antibody responses to vaccination, with decreased spacing improving hemagglutination inhibition and neutralization potency.

Stepwise design of pseudosymmetric protein hetero-oligomers

The paper introduces a method to design pseudosymmetric protein hetero-oligomers by redesigning symmetric homo-oligomers and recombining them to form new hetero-oligomers with high structural specificity.

Modulation of FGF pathway signaling and vascular differentiation using designed oligomeric assemblies

This study designs synthetic oligomeric ligands to modulate FGFR signaling and shows their impact on vascular cell fate decisions.

Precisely patterned nanofibers made from extendable protein multiplexes

The paper designs extendable protein multiplexes with symmetric architectures to create precisely patterned nanofibers through controlled repeat propagation and hydrophilic patch placement.

Hallucinating protein assemblies

Deep network-based protein design generates symmetric homo-oligomers with high structural accuracy, demonstrating the potential for creating novel nanomachines and biomaterials.

Improving the secretion of designed protein assemblies through negative design of cryptic transmembrane domains

This study identifies cryptic transmembrane domains in designed protein nanoparticles that hinder secretion and introduces a computational tool, Degreaser, to remove them while maintaining stability, improving secretion efficiency.

KAT5 regulates neurodevelopmental states associated with G0-like populations in glioblastoma

This study identifies KAT5 as a regulator of G0-like states in glioblastoma, showing its role in suppressing non-dividing subpopulations and associating with worse patient outcomes.

Distinct sensitivities to SARS-CoV-2 variants in vaccinated humans and mice

This study compares neutralizing antibody responses to SARS-CoV-2 variants in vaccinated humans and mice, finding that mice do not accurately reflect the breadth and potency seen in humans.

Molecular basis of immune evasion by the delta and kappa SARS-CoV-2 variants

This study investigates how delta and kappa SARS-CoV-2 variants evade immune responses by altering antigenic sites and reducing ACE2 binding affinity.

Qualification of ELISA and neutralization methodologies to measure SARS-CoV-2 humoral immunity using human clinical samples

This paper qualifies ELISA and neutralization assays to measure SARS-CoV-2 humoral immunity using clinical samples, evaluating antibody titers and functional neutralization capacity.

High-affinity, neutralizing antibodies to SARS-CoV-2 can be made in the absence of T follicular helper cells

The paper shows that high-affinity, neutralizing antibodies against SARS-CoV-2 can be produced without T follicular helper cells through alternative pathways.

Functional dissection of human mitotic proteins using CRISPR-Cas9 tiling screens

The paper uses CRISPR-Cas9 tiling screens to identify functional domains in human mitotic proteins, revealing new regions essential for cell proliferation and chromosome segregation.

Stabilization of the SARS-CoV-2 Spike receptor-binding domain using deep mutational scanning and structure-based design

This paper designs stabilized SARS-CoV-2 RBD variants using deep mutational scanning and structure-based design, showing improved thermal stability and manufacturability for vaccine applications.

Elicitation of broadly protective sarbecovirus immunity by receptor-binding domain nanoparticle vaccines

This study shows that a SARS-CoV-2 RBD nanoparticle vaccine protects against SARS-CoV-2 and related sarbecoviruses, including variants, in mice and non-human primates.

Ultrapotent miniproteins targeting the receptor-binding domain protect against SARS-CoV-2 infection and disease in mice

This study evaluates the protective efficacy of modified miniproteins against SARS-CoV-2 in mice, showing reduced viral burden and prevention of lung disease.

Adjuvanting a subunit SARS-CoV-2 nanoparticle vaccine to induce protective immunity in non-human primates

This study evaluates adjuvants for a subunit SARS-CoV-2 nanoparticle vaccine in non-human primates, showing durable neutralizing antibody responses and protection against infection.

F-domain valency determines outcome of signaling through the angiopoietin pathway

The paper investigates how the valency of F-domain scaffolds affects signaling through the angiopoietin pathway, finding that higher valency mimics Ang1's pro-angiogenic effects while lower valency mimics Ang2's antagonistic effects.

Elicitation of potent neutralizing antibody responses by designed protein nanoparticle vaccines for SARS-CoV-2

This study designs SARS-CoV-2 nanoparticle vaccines that induce strong neutralizing antibodies in mice, with higher titers and lower doses than existing trimer vaccines.

Elicitation of broadly protective immunity to influenza by multivalent hemagglutinin nanoparticle vaccines

Nanoparticle immunogens with four seasonal influenza hemagglutinins elicit neutralizing antibodies against both the head and stem, providing broad protection against diverse influenza strains.

Neural G0: a quiescent-like state found in neuroepithelial-derived cells and glioma

The paper identifies a quiescent-like state, Neural G0, in human neural stem cells and gliomas using scRNA-seq, linking it to tumor aggressiveness and survival.

N6-methyladenosine mRNA marking promotes selective translation of regulons required for human erythropoiesis

The paper identifies m6A mRNA methylation as a regulator of erythropoiesis by promoting the translation of key genes involved in erythroid lineage specification.