Agent-based models help interpret patterns of clinical drug resistance by contextualizing competition between distinct drug failure modes.
S. M. Leighow, B. Landry, M. J. Lee, S. R. Peyton, J. R. Pritchard
The paper uses agent-based models to show that microenvironmental resistance can compete with genetic resistance in tumors, explaining observed diversity in drug failure modes.
bioRxiv · Feb 25, 2022Bioengineering