Author

S. R. Peyton

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioengineering· 4 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 4 Approach:experimental assay· 4 Organism:human· 4 Assay:bulk RNA-seq· 2 Research Focus:cancer & tumor microenvironment· 2 Research Focus:cell type annotation· 1 Research Focus:clustering· 1 Approach:deep learning· 1

Frequent Co-Authors

A. D. Schwartz· 2 shared A. N. Kundu· 2 shared C. E. Dougan· 2 shared M. J. Lee· 2 shared A. J. Crosby· 1 shared A. Kilic· 1 shared A. Panagiotou· 1 shared B. D. Landry· 1 shared

Activity by Year

2017-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 13 mutual co-author links

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2 shared papersBioengineering

A. D. Schwartz

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Author profile →

5 papers

Recent·Most cited

Tenascin-C activation of lung fibroblasts in a 3D synthetic lung extracellular matrix mimic

A. N. Kundu, C. E. Dougan, S. Mahmoud, A. Kilic, A. Panagiotou, N. Irakoze, N. Richbourg, S. R. Peyton

This study develops a synthetic lung ECM hydrogel to study fibroblast activation, showing that tenascin-C and TGF-β1 activate fibroblasts in the hydrogel similar to in vivo responses.

bioRxiv · Feb 24, 2023Bioengineering

Agent-based models help interpret patterns of clinical drug resistance by contextualizing competition between distinct drug failure modes.

S. M. Leighow, B. Landry, M. J. Lee, S. R. Peyton, J. R. Pritchard

The paper uses agent-based models to show that microenvironmental resistance can compete with genetic resistance in tumors, explaining observed diversity in drug failure modes.

bioRxiv · Feb 25, 2022Bioengineering

Cross-Platform Mechanical Characterization of Lung Tissue

S. R. Polio, A. N. Kundu, C. E. Dougan, N. P. Birch, D. E. Aurien-Blajeni, J. D. Schiffman, A. J. Crosby, S. R. Peyton

This study compares mechanical characterization techniques to quantify lung tissue modulus, finding cavitation rheology provides microscale measurements on intact tissue with higher modulus values.

bioRxiv · May 16, 2018Bioengineering

Integrin α6 and EGFR Signaling Converge at Mechanosensitive Calpain 2

A. D. Schwartz, C. L. Hall, L. E. Barney, C. C. Babbitt, S. R. Peyton

The paper investigates how integrin α6 and EGFR signaling converge through mechanosensitive calpain 2 in carcinoma progression.

bioRxiv · Apr 15, 2018Bioengineering

Fibroblasts from metastatic sites induce broad-spectrum drug desensitization via modulation of mitochondrial priming

B. D. Landry, T. Leete, R. Richards, P. Cruz-Gordillo, G. Ren, A. D. Schwartz, S. R. Peyton, M. J. Lee

The paper identifies how fibroblasts from metastatic sites modulate mitochondrial priming in tumor cells, leading to drug desensitization through inflammatory cytokine secretion.

bioRxiv · Oct 2, 2017Cancer Biology