M. J. Lee

Calcineurin promotes adaptation to chronic stress through two distinct mechanisms

This study shows calcineurin (CN) helps yeast adapt to chronic stress through two distinct mechanisms involving Crz1 and Crz1-independent pathways.

UBE2N is essential for maintenance of skin homeostasis and suppression of inflammation

This study shows that UBE2N is crucial for skin homeostasis and inflammation suppression, with its loss causing inflammatory skin defects and identifying IRAK1/4 as a therapeutic target.

NK cell-monocyte crosstalk underlies NK cell activation in severe COVID-19

This study identifies NK cell-monocyte interactions as a driver of NK cell activation and dysfunction in severe COVID-19 through computational and in vitro experiments.

Functional genomics reveals an off-target dependency of drug synergy in gastric cancer therapy

The paper identifies an off-target dependency of erlotinib in enhancing SN38's synergistic effect in gastric cancer through functional genomics.

Enhanced functionalities of immune cells separated by microfludic lattice: assessment based on holotomography

This study compares microfluidic and centrifugation methods for isolating white blood cells, finding microfluidic separation better preserves cell functionality.

Functional interaction of torsinA and its activators in liver lipid metabolism

The paper shows that torsinA and its activators LAP1 and LULL1 regulate liver triglyceride secretion and steatosis in mice.

Label-free histological analysis of retrieved thrombi in acute ischemic stroke using optical diffraction tomography and deep learning

This study uses optical diffraction tomography and deep learning to automate thrombus composition analysis in acute ischemic stroke, achieving high accuracy and reducing labor.

High-resolution assessment of multidimensional cellular mechanics using label-free refractive-index traction force microscopy

This paper introduces RI-TFM, a high-speed label-free technique for 3D cellular mechanics, and demonstrates its ability to measure traction forces and morphology in cells.

p53 controls choice between apoptotic and non-apoptotic death following DNA damage

This study shows p53 regulates whether DNA damage triggers apoptosis or non-apoptotic death, revealing that p53-deficient cells die via MPT-driven necrosis due to high basal respiration.

How well do rudimentary plasticity rules predict adult visual object learning?

This paper evaluates whether simple plasticity rules combined with visual representations can predict human object learning behavior using psychophysics experiments and computational models.

SARS-CoV-2 escapes direct NK cell killing through Nsp1-mediated downregulation of ligands for NKG2D

This study shows SARS-CoV-2 evades NK cell killing by downregulating NKG2D ligands via Nsp1, reducing NK cell cytotoxicity against infected cells.

An affinity for brainstem microglia in pediatric high grade gliomas of brainstem origin

This study identifies IL33 as a factor promoting DIPG proliferation in the brainstem microenvironment, highlighting its role in the spatiotemporal pattern of pediatric high-grade gliomas.

ECPAS/Ecm29-Mediated 26S Proteasome Disassembly Is an Adaptive Response to Glucose Starvation

This study shows that ECPAS-mediated 26S proteasome disassembly into 20S and 19S subcomplexes occurs during glucose starvation, enhancing proteolysis and cell survival.

Agent-based models help interpret patterns of clinical drug resistance by contextualizing competition between distinct drug failure modes.

The paper uses agent-based models to show that microenvironmental resistance can compete with genetic resistance in tumors, explaining observed diversity in drug failure modes.

Deep Phenotypic Analysis of Blood and Lymphoid T and NK Cells from HIV+ Controllers and Non-Controllers

This study compares T and NK cell phenotypes in blood and lymph nodes of HIV+ controllers and ART-treated individuals, finding distinct cellular features in lymphoid tissues.

Multi-omic profiling reveals widespread dysregulation of innate immunity and hematopoiesis in COVID-19

Single-cell multi-omic profiling identifies immune dysregulation in severe COVID-19, including neutrophil hyperactivation and anti-inflammatory monocytes.

ELP-dependent expression of MCL1 promotes resistance to EGFR inhibition in triple-negative breast cancer cells

The study identifies the ELP complex as a mediator of resistance to EGFR inhibition in TNBC by promoting MCL1 expression, suggesting co-targeting EGFR and MCL1 as a therapeutic strategy.

Comparative analysis of primer-probe sets for the laboratory confirmation of SARS-CoV-2

This study compares the sensitivity of primer-probe sets for detecting SARS-CoV-2 RNA in N and Orf1 genes, identifying the most sensitive sets for each.

Fibroblasts from metastatic sites induce broad-spectrum drug desensitization via modulation of mitochondrial priming

The paper identifies how fibroblasts from metastatic sites modulate mitochondrial priming in tumor cells, leading to drug desensitization through inflammatory cytokine secretion.