Structural basis for activation of DNMT1
A. Kikuchi, H. Onoda, K. Yamaguchi, S. Kori, S. Matsuzawa, Y. Chiba, S. Tanimoto, S. Yoshimi, H. Sato, A. Yamagata, M. Shirouzu, N. Adachi, J. Sharif, H. Koseki, A. Nishiyama, , K. Arita
This study determines the cryo-EM structure of DNMT1 bound to hemimethylated DNA and ubiquitinated histone H3, revealing a mechanism for its activation.
bioRxiv · Jun 16, 2022Biochemistry