Y. Chiba

Structure of human DPPA3 bound to the UHRF1 PHD finger reveals its functional and structural differences from mouse DPPA3

This study compares the structural and functional differences between human and mouse DPPA3 in binding to UHRF1 PHD finger, showing weaker human DPPA3 binding and reduced inhibition of UHRF1 chromatin binding.

Rechargeable Biomineral Induced by Sulfate Reducing Bacterium Cupidesulfovibrio sp. HK-II

This study investigates biogenic mackinawite produced by Cupidesulfovibrio sp. HK-II, showing it exhibits rechargeable properties through redox reactions and structural changes during discharge and recharge.

Diverse Phosphoserine Phosphatases Exhibit Maximum Activity at an Intermediate Binding Affinity in Accord with the Sabatier Principle of Catalysis

This paper shows that phosphoserine phosphatases exhibit maximum activity at an intermediate binding affinity, supporting the Sabatier principle of catalysis when considering both Km and the product release rate constant.

Universal Design Principle to Enhance Enzymatic Activity using the Substrate Affinity

The paper demonstrates that setting the Michaelis-Menten constant (Km) equal to substrate concentration (S) maximizes enzymatic activity, providing a quantitative guideline for enzyme optimization.

Human Dectin-1 is O-glycosylated and serves as a ligand for C-type lectin receptor CLEC-2

This study identifies human Dectin-1 as a ligand for CLEC-2, showing its O-glycosylation enables it to function as a physiological ligand for immune regulation.

Structural basis for activation of DNMT1

This study determines the cryo-EM structure of DNMT1 bound to hemimethylated DNA and ubiquitinated histone H3, revealing a mechanism for its activation.

Structural basis for the unique multifaceted interaction of DPPA3 with the UHRF1 PHD finger

This study determines the structure of the mouse UHRF1 PHD domain complexed with DPPA3, revealing how DPPA3 inhibits UHRF1 chromatin localization through unique interactions.

Thoracic crop formation is spatiotemporally coordinated with flight muscle histolysis during claustral colony foundation of a Lasius japonicus queen

Discovery of divided RdRp sequences and a hitherto unknown genomic complexity in fungal viruses

The paper identifies divided RdRp sequences and novel genomic structures in fungal viruses using FLDS technology, revealing previously hidden diversity and challenging existing views on RdRp gene organization.