K. Yamaguchi

Colonization by orchid mycorrhizal fungi primes induced systemic resistance against a necrotrophic pathogen

This study shows that colonization by a compatible orchid mycorrhizal fungus primes induced systemic resistance in Bletilla striata against a necrotrophic pathogen by modulating jasmonate and ethylene pathways, similar to arbuscular mycorrhizal plants.

Effect of iris pigmentation of blue and brown eyed individuals with European ancestry on ability to see in low light conditions after a short-term dark adaption period.

This study finds blue-eyed individuals have better low-light vision than brown-eyed individuals after dark adaptation, suggesting depigmented irises may offer an adaptive advantage.

Paroxetine-induced transient apoptosis with delayed neurogenesis induces brain remodeling in developing zebrafish

This study shows that early paroxetine exposure in zebrafish embryos causes transient apoptosis, delayed neurogenesis, and brain remodeling linked to ASD-like social behavior impairments.

Microbiome ssRNA as an environmental cue to activate TLR13-dependent tissue-protective programs in CD5Lhi hepatic macrophages

The paper shows that microbiome ssRNA activates TLR13 in hepatic macrophages to drive tissue-protective responses, leading to resistance against acute liver injury in Rnaset2-/- mice.

Orchid seed germination through auto-activation of mycorrhizal symbiosis signaling regulated by gibberellin

This study investigates how gibberellin (GA) affects Bletilla striata seed germination and mycorrhizal symbiosis, revealing that GA inactivation enables auto-activation of the symbiosis pathway.

Monoterpene glucosides accumulated in Eustoma grandiflorum roots promote hyphal branching in arbuscular mycorrhizal fungi

Single cell transcriptomics identifies adipose tissue CD271+ progenitors for enhanced angiogenesis in limb ischemia

This study identifies CD271+ progenitors from subcutaneous adipose tissue with enhanced angiogenic properties for treating limb ischemia.

A bispecific antibody NXT007 exerts a hemostatic activity in hemophilia A monkeys enough to keep a non-hemophiliac state

This paper reports a bispecific antibody NXT007 that shows improved hemostatic activity in hemophilia A monkeys, equivalent to FVIII levels, with lower dosing requirements and longer intervals.

TLR7/8 stress response drives histiocytosis in SLC29A3 disorders

This study identifies TLR7/8 as drivers of histiocytosis in SLC29A3 disorders by responding to lysosomal nucleoside stress and enhancing monocyte proliferation and phagocyte maturation.

Elasmobranch genome sequencing reveals evolutionary trends of vertebrate karyotypic organization

This study sequenced elasmobranch genomes to reveal evolutionary trends in vertebrate karyotypic organization, identifying a shark X chromosome and patterns of intragenomic heterogeneity.

CiDRE+ M2c macrophages hijacked by SARS-CoV-2 cause COVID-19 severity

This study identifies IL-10-driven M2c macrophages as key contributors to severe COVID-19 by facilitating SARS-CoV-2 infection and highlights CiDRE as a potential therapeutic target.

Onecut1 partially contributes to liver progenitor cell transition and acquisition of metastatic potential in hepatocellular carcinoma.

Polycomb repressive complex 1.1 coordinates homeostatic and emergency myelopoiesis

This study identifies PRC1.1 as a regulator of homeostatic and emergency myelopoiesis, showing its role in balancing myeloid differentiation and preventing transformation.

Tertiary lymphoid structures induced by CXCL13-producing CD4+ T cells increase tumor infiltrating CD8+ T cells and B cells in ovarian cancer

This study shows that CXCL13-producing CD4+ T cells induce tertiary lymphoid structures (TLSs) in ovarian cancer, increasing CD8+ T cell and B cell infiltration and improving patient prognosis.

Structural basis for activation of DNMT1

This study determines the cryo-EM structure of DNMT1 bound to hemimethylated DNA and ubiquitinated histone H3, revealing a mechanism for its activation.

Single-nucleotide substitution determines pollen production in Japanese cedar

This study identifies a single-nucleotide substitution in the TKPR1 gene that determines pollen production in Japanese cedar and suggests its potential application in creating pollen-free plants.

Lipid-correlated alterations in the transcriptome are enriched in several specific pathways in the postmortem prefrontal cortex of Japanese patients with schizophrenia

The paper integrates transcriptome and lipidome data from postmortem prefrontal cortex samples of schizophrenia patients to identify lipid-correlated gene expression changes in specific pathways.

Engineering of an electrically charged hydrogel implanted into a traumatic brain injury model for stepwise neuronal tissue reconstruction

The paper describes a two-step method using charged hydrogels and neural stem cell injection to promote brain tissue reconstruction after traumatic injury.

Conformational switch in the alpha-synuclein C-terminus domain directs its fibril polymorphs

This study identifies a conformational switch in the alpha-synuclein C-terminus domain that determines fibril polymorphs by altering morphology in response to ionic strength and temperature.

Macromolecular crowding and supersaturation protect hemodialysis patients from the onset of dialysis-related amyloidosis

This study identifies serum albumin concentration as a tertiary risk factor for dialysis-related amyloidosis, showing that maintenance dialysis improves outcomes by increasing serum component concentrations.

ForestScanner: A mobile application for measuring and mapping trees with LiDAR-equipped iPhone and iPad

ForestScanner enables rapid, accurate, and cost-effective forest inventories using LiDAR-equipped iPhones or iPads, reducing labor and time compared to traditional methods.

The rice OsERF101 transcription factor regulates the NLR Xa1-mediated perception of TAL effectors and Xa1-mediated immunity

This study identifies OsERF101 as a regulator of Xa1-mediated immunity in rice by interacting with TAL effectors and modulating immune responses.

Whale shark rhodopsin adapted to its vertically wide-ranging lifestyle

This study identifies two amino acid sites in whale shark rhodopsin that contribute to its blue shift and thermal stability, enabling its wide vertical range.

Assessing the impacts of climate change on reproductive phenology in tropical rainforests of Southeast Asia

The paper analyzes climate change impacts on reproductive phenology in Southeast Asian tropical rainforests, finding decreased flowering and fruiting species proportions and reduced low-temperature flowering cues.

Conservation and diversity in transcriptional responses among host plants forming distinct arbuscular mycorrhizal morphotypes

The paper investigates transcriptional responses to arbuscular mycorrhizal (AM) symbiosis and gibberellin (GA) treatment in three host plants with distinct AM morphotypes, finding conserved and divergent gene expression patterns.

Transcriptomic analysis of resistant and susceptible responses in a new model root-knot nematode infection system using Solanum torvum and Meloidogyne arenaria

This study compares gene expression responses in Solanum torvum infected with two Meloidogyne arenaria pathotypes, identifying distinct molecular mechanisms of resistance and susceptibility.

The anti-tubercular activity of simvastatin is mediated by cholesterol-dependent regulation of autophagy via the AMPK-mTORC1-TFEB axis

This study shows simvastatin's anti-tubercular effect is due to cholesterol inhibition, which activates AMPK, blocks mTORC1, and promotes TFEB-driven autophagy.

Switching secretory pathway direction for organelle acquisition in plants

The paper identifies a mechanism in liverworts for acquiring oil bodies through switching secretory pathway direction during cellular phase transitions.

The RopGEF KARAPPO is Essential for the Initiation of Vegetative Reproduction in Marchantia

This study identifies KARAPPO, a RopGEF, as essential for initiating vegetative reproduction in Marchantia by promoting gemma initial formation through Rop signaling.

Repeated inversions at the pannier intron drive diversification of intraspecific colour patterns of ladybird beetles

The paper identifies pannier as a key regulatory gene for color pattern variation in ladybird beetles and shows that inversions and cis-regulatory changes at this gene drive intraspecific diversity.