Author

S. McKnight

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Research Focus:protein folding & dynamics· 2 Assay:protein structure· 1 Assay:proteomics· 1

Frequent Co-Authors

L. Sutherland· 2 shared X. Zhou· 2 shared G. Liszczak· 1 shared J. Gu· 1 shared J. Rizo· 1 shared K. Jaczynska· 1 shared K. Tashiro· 1 shared L. Sumrow· 1 shared

Activity by Year

2021-2023 · peak 1/yr

Co-Author Collaboration Network

9 top collaborators · 24 mutual co-author links

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2 shared papersBiochemistry

L. Sutherland

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2 papers

Recent·Most cited

Oxidative regulation of TDP-43 self-association by a beta-to-alpha conformational switch

J. Gu, X. Zhou, L. Sutherland, M. Kato, K. Jaczynska, J. Rizo, S. McKnight

This paper shows that oxidative modification of TDP-43's low complexity domain induces a beta-to-alpha conformational switch, disrupting self-association and phase separation.

bioRxiv · Aug 29, 2023 · PreprintBiochemistry

Tracing the genetics of neurological disease to the mutation-directed addition of single hydrogen bonds

x. zhou, K. Tashiro, L. Sumrow, L. Sutherland, G. Liszczak, S. McKnight

The paper identifies recurrent mutations in low complexity domains that introduce single hydrogen bonds, and shows that methylation can restore normal protein function.

bioRxiv · Dec 5, 2021 · PreprintBiochemistry