M. Kato

Cryo-EM and Solid State NMR Together Provide a More Comprehensive Structural Investigation of Protein Fibrils

This study combines cryo-EM and solid state NMR to better understand the structure of Tm1-LC fibrils, showing how each technique complements the other in revealing molecular conformations.

Expression of mRNAs Encoding Hypothalamic Small Proteins, Neurosecretory Protein GL and Neurosecretory Protein GM, in the Japanese Quail, Coturnix japonica

This study identifies and localizes NPGL and NPGM mRNA expression in the Japanese quail hypothalamus, showing sex-specific and fasting-responsive patterns.

Oxidative regulation of TDP-43 self-association by a beta-to-alpha conformational switch

This paper shows that oxidative modification of TDP-43's low complexity domain induces a beta-to-alpha conformational switch, disrupting self-association and phase separation.

Global changes in open reading frame dominance of RNAs during cancer initiation and progression

The paper measures ORF dominance in cancer and finds it increases with carcinogenesis, correlates with translation, and blurs coding/noncoding boundaries before metastasis.

Molecular Weight-dependent Diffusion, Biodistribution, and Clearance Behavior of Tetra-armed Poly(ethylene glycol) Subcutaneously Injected into the Back of Mice

This study examines how molecular weight affects the diffusion, biodistribution, and clearance of four-armed PEGs injected subcutaneously into mice.

Intra and interspecific diversity in a tropical plant clade alter herbivory and ecosystem resilience

The paper examines how changes in plant diversity within and between species affect herbivory and ecosystem resilience in tropical systems.

In vivo reprogramming of wound-resident cells generates skin with hair

This study reprograms wound-resident cells in adult mice to generate skin with hair follicles, demonstrating de novo appendage formation.

Redox-active compound generated by bacterial crosstalk induces hypha branching in Streptomyces species

This paper identifies pyrogallol, a redox-active compound from bacterial crosstalk, as an inducer of hyphae branching in Streptomyces species via reactive oxygen species.

Affective arousal explains infant gaze following under various social context

This study shows that infant gaze following is influenced by social context through physiological arousal, mediated by heart rate changes in response to reliable faces and eye contact.

Glutamine deficiency in solid tumors confers resistance to ribosomal RNA synthesis inhibitors

The paper shows that glutamine deficiency in cancer cells prevents p53 activation by rRNA synthesis inhibitors, promoting survival during nutrient stress.

Combined free energy calculation and machine learning methods for understanding ligand unbinding kinetics

This paper develops a computational method combining free energy calculations and machine learning to predict ligand unbinding kinetics and identify key interactions for drug design.

The Low Complexity Domain of the FUS RNA Binding Protein Self-assembles via the Mutually Exclusive Use of Two Distinct Cross-β Cores

This paper identifies two distinct cross-β cores in the FUS LC domain that function mutually exclusively, and shows disease mutations disrupt this balance.

A Novel Hypothalamic Factor, Neurosecretory Protein GM, Causes Fat Deposition in Chicks

This study shows that chronic intracerebroventricular infusion of NPGM in chicks increases body mass, water intake, and abdominal fat mass without affecting food intake or blood glucose.

Protein-coding potential of RNAs measured by potentially translated island scores

This study introduces a PTI score to measure RNA coding potential and finds it correlates with translation and overlaps between coding and noncoding RNAs in different species.

Genome-wide association study of gastric cancer- and duodenal ulcer-derived Helicobacter pylori strains reveals discriminatory amino acid differences and novel oncoprotein candidates

This study uses GWAS to identify genetic variations in H. pylori strains associated with gastric cancer and duodenal ulcers, revealing amino acid differences and novel oncoprotein candidates.

Mutation-specific pathophysiological mechanisms define different neurodevelopmental disorders associated with SATB1 dysfunction

The paper identifies mutation-specific pathophysiological mechanisms in SATB1 variants causing distinct neurodevelopmental disorders.

Elucidation and control of low and high active populations of alkaline phosphatase molecules for quantitative digital bioassay

This study quantitatively analyzes single-molecule ALP activity, revealing two distinct populations with different catalytic properties and demonstrating methods to generate homogeneous ALP populations.

Dynamic structural order of a low complexity domain facilitates assembly of intermediate filaments

The paper shows that low complexity domains in Drosophila Tm1 proteins form labile cross-β interactions, facilitating intermediate filament assembly through dynamic structural transitions.

Transiently structured head domains control intermediate filament assembly

This study shows how low complexity head domains transiently form structured β-strand-enriched polymers that influence intermediate filament assembly and cell morphology.

Redox-mediated regulation of a labile, evolutionarily conserved cross-β structure formed by the TDP43 low complexity domain

This study shows that redox regulation controls TDP43 low complexity domain aggregation into cross-β polymers, with implications for neurodegenerative diseases.

Cables2 Is a novel Smad2-regulatory factor essential for early embryonic development in mice

This study identifies Cables2 as a Smad2-regulatory factor required for early embryonic development in mice, showing its role in gastrulation and gene expression patterns.

SMAD3 Determines Conventional versus Plasmacytoid Dendritic Cell Fates

This study identifies SMAD3 as a key regulator determining conventional DC versus plasmacytoid DC differentiation through distinct gene regulatory mechanisms.

Life in coastal pebble sediment: Unique interstitial organism community and selective feeding on meiobenthos by interstitial fishes (Luciogobius: Gobiidae)

This study examines the diet and interstitial organism communities of two Luciogobius goby species, revealing their exclusive reliance on meiobenthos and selective feeding preferences.

PHASE TRANSITIONED NUCLEAR OSKAR PROMOTES CELL DIVISION OF DROSOPHILA PRIMORDIAL GERM CELLS

The paper investigates nuclear germ granules in Drosophila PGCs, showing Oskar drives their formation and function in cell division.

Evolution of shell flattening and the loss of coiling in top shells (Gastropoda: Trochidae: Fossarininae) on wave-swept rock reefs

This study describes the evolution of limpet-like, zygomorphic shells in Roya snails, which enables wave tolerance and a unique lifestyle on wave-swept rock reefs.