Connexin 43 and Cell Culture Substrate Differentially Regulate OCY454 Osteocytic Differentiation and Signaling to Primary Bone Cells
G. A. Hoppock, E. G. Buettmann, J. A. Denisco, G. M. Goldscheitter, S. N. Condyles, O. J. Juhl, M. A. Friedman, Y. Zhang, H. J. Donahue
This study compares 3D and 2D culture of Cx43-deficient OCY454 osteocytes, finding that 3D cultures enhance differentiation and bone remodeling factor secretion, while Cx43 deficiency increases signaling to promote osteoblast and osteoclast formation.
bioRxiv · Jun 23, 2023Cancer Biology