Author

S. N. Thomas

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Assay:proteomics· 2 Research Focus:benchmarking· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Approach:statistical model· 1

Frequent Co-Authors

A. H. K. Ashkezari· 1 shared A. M. Rosado· 1 shared B. Friedrich· 1 shared B. Kinney· 1 shared C. Ge· 1 shared C. Zhu· 1 shared D. M. Francis· 1 shared D. W. Chan· 1 shared

Activity by Year

2019-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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1 shared paperImmunology

A. H. K. Ashkezari

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Author profile →

2 papers

Recent·Most cited

Tumor microenvironments impair T cell receptor affinity and function

Z. Yuan, M. J. O'Melia, K. Li, J. Lyu, A. M. Rosado, V. E. Watson, A. H. K. Ashkezari, F. Zhou, V. Kansal, B. Kinney, S. Travaglino, L. O. Doudy, R. K. Noel, S. N. Lucas, S. L. Kong, , C. Zhu

This study shows that CD8+ T cells in the tumor microenvironment have reduced TCR-pMHC affinity and function, impairing their anti-tumor activity.

bioRxiv · Sep 11, 2022 · PreprintImmunology

Orthogonal proteomic platforms and their implications for the stable classification of high-grade serous ovarian cancer subtypes

S. N. Thomas, B. Friedrich, M. Schnaubelt, D. W. Chan, H. Zhang, R. Aebersold

This study compares two proteomic methods, 2DLC-MS/MS and SWATH-MS, showing they both identify differentially expressed proteins in HGSOC subtypes but differ in workflow complexity and proteome coverage.

bioRxiv · Oct 3, 2019Cancer Biology