Author

S. Travaglino

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 3

Signature Assays, Organisms & Methods

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Organism:human· 3 Assay:proteomics· 3 Research Focus:cell signaling & trafficking· 2 Approach:biophysical modeling· 1 Research Focus:cancer & tumor microenvironment· 1 Approach:deep learning· 1 Approach:experimental assay· 1 Approach:statistical model· 1

Frequent Co-Authors

C. Zhu· 3 shared C. Ge· 2 shared J. Lyu· 2 shared Z. Yuan· 2 shared A. H. K. Ashkezari· 1 shared A. M. Rosado· 1 shared A. Natarajan· 1 shared A. Singh· 1 shared

Activity by Year

2022-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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3 shared papersImmunology

C. Zhu

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3 papers

Recent·Most cited

Mechanotransduction governs CD40 function and underlies X-linked Hyper IgM syndrome

H.-K. Choi, S. Travaglino, M. Munchhalfen, R. Gorg, Z. Zhong, J. Lyu, D. M. Reyes-Aguilar, J. Wienands, A. Singh, C. Zhu

This study shows that CD40-CD40L interactions form catch bonds that enhance B cell signaling and antibody class-switch, and mutations in CD40L disrupt this mechanism, causing X-linked Hyper IgM syndrome.

bioRxiv · Jul 23, 2023Immunology

Tumor microenvironments impair T cell receptor affinity and function

Z. Yuan, M. J. O'Melia, K. Li, J. Lyu, A. M. Rosado, V. E. Watson, A. H. K. Ashkezari, F. Zhou, V. Kansal, B. Kinney, S. Travaglino, L. O. Doudy, R. K. Noel, S. N. Lucas, S. L. Kong, , C. Zhu

This study shows that CD8+ T cells in the tumor microenvironment have reduced TCR-pMHC affinity and function, impairing their anti-tumor activity.

bioRxiv · Sep 11, 2022 · PreprintImmunology

Cooperative cis-interactions between ectodomains of TCRαβ CD3 subunits enable mechanotransduction

P. Cong, A. Natarajan, Z. Yuan, C. Ge, S. Travaglino, R. Dezhkam, S. Beesam, X. Li, D. Grazette, M. Krogsgaard, C. Zhu

The paper quantifies cooperative cis-interactions between TCRβ and CD3 subunits, showing they form catch bonds that mechanically regulate TCR signaling.

bioRxiv · Apr 14, 2022 · PreprintImmunology