Legionella pneumophila inhibits type I interferon signaling to avoid cell-intrinsic host cell defense.
C. N. S. Allen, D. A. Banks, M. Shuster, S. N. Vogel, T. J. O'Connor, V. Briken
This study shows Legionella pneumophila inhibits the IFN-β signaling pathway but not IFN-ψ, using its type IV secretion system, and this inhibition occurs downstream of STAT1 and STAT2 phosphorylation.
bioRxiv · Dec 21, 2022 · PreprintMicrobiology