V. Briken

da_Tracker: Automated workflow for high throughput single cell and single phagosome tracking in infected cells.

The paper introduces da_Tracker, an automated workflow for high-throughput single-cell and single-phagosome tracking in infected cells, enabling quantitative analysis of pathogen-host interactions.

Salmonella Typhimurium infection inhibits macrophage IFNbeta signaling in a TLR4-dependent manner

This study shows Salmonella Typhimurium inhibits macrophage IFNbeta signaling via TLR4, but IFNbeta does not affect host defense against STm.

BBQ methods: Streamlined workflows for Bacterial Burden Quantification in infected cells by confocal microscopy

This paper introduces two automated methods for quantifying bacterial burden in macrophages using confocal microscopy, validated with Salmonella and Mycobacterium models.

Legionella pneumophila inhibits type I interferon signaling to avoid cell-intrinsic host cell defense.

This study shows Legionella pneumophila inhibits the IFN-β signaling pathway but not IFN-ψ, using its type IV secretion system, and this inhibition occurs downstream of STAT1 and STAT2 phosphorylation.

Dynamic Interplay of Autophagy and Membrane Repair During Mycobacterium tuberculosis Infection

This study investigates LC3 recruitment to Mtb-containing vacuoles in macrophages, revealing its variability and lack of correlation with autophagosome maturation or membrane repair.

Mycobacterium tuberculosis inhibits autocrine type I interferon signaling to increase intracellular survival.

This study shows Mycobacterium tuberculosis inhibits IFN-β signaling in macrophages to enhance its survival by reducing phosphorylation of JAK1, TYK2, STAT1, and STAT2.