Frequent extrachromosomal oncogene amplification drives aggressive tumors
H. Kim, N. Nguyen, K. Turner, S. Wu, J. Liu, V. Deshpande, S. Namburi, H. Y. Chang, C. Beck, P. S. Mischel, V. Bafna, R. G. W. Verhaak
This study shows that extrachromosomal DNA amplification of oncogenes is common in human cancers and is associated with worse patient outcomes.
bioRxiv · Nov 28, 2019 · PreprintCancer Biology