Author

V. Deshpande

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3 Biophysics· 2 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Approach:statistical model· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:cell type annotation· 2 Research Focus:development & morphogenesis· 2 Research Focus:differential expression· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

A. DeSimone· 2 shared A. Ippolito· 1 shared A. K. Coley· 1 shared A. Pankaj· 1 shared A. Vigliotti· 1 shared B. K. Patel· 1 shared B. Sie· 1 shared C. Beck· 1 shared

Activity by Year

2018-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 10 mutual co-author links

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Curved chords = mutual co-authorship

2 shared papersBiophysics

A. DeSimone

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Single Cell Spatial Transcriptomic Profiling Identifies a LINE1 Associated Disarrayed Immune Microenvironment in Hepatocellular Carcinoma

A. K. Coley, C. Nawrocki, B. K. Patel, A. Pankaj, Z. Guo, M. J. Emmett, E. R. Lang, Y. Song, K. H. Xu, C. R. Ferrone, V. Deshpande, L. T. Nieman, M. Aryee, J. W. Franses, D. T. Ting

This study uses single cell spatial transcriptomics to show LINE1 repeat RNA expression in HCC correlates with a disorganized immune microenvironment and poor patient survival.

bioRxiv · Dec 4, 2023 · PreprintCancer Biology

Lymphatics constitute a novel component of the intestinal stem cell niche

N. Goto, S. Imada, V. Deshpande, O. H. Yilmaz

This study identifies lymphatic endothelial cells (LECs) as a novel component of the intestinal stem cell (ISC) niche, alongside Rspo3+Grem1+ fibroblasts (RGFs), which together provide essential RSPO3 for ISC maintenance and regeneration.

bioRxiv · Jan 28, 2022 · PreprintCell Biology

Contact guidance as a consequence of coupled morphological evolution and motility of adherent cells

A. Ippolito, A. DeSimone, V. Deshpande

The paper uses a Langevin model to show how non-thermal fluctuations drive cell morphology and motility, leading to contact guidance on patterned substrates.

bioRxiv · Jun 9, 2021Biophysics

Frequent extrachromosomal oncogene amplification drives aggressive tumors

H. Kim, N. Nguyen, K. Turner, S. Wu, J. Liu, V. Deshpande, S. Namburi, H. Y. Chang, C. Beck, P. S. Mischel, V. Bafna, R. G. W. Verhaak

This study shows that extrachromosomal DNA amplification of oncogenes is common in human cancers and is associated with worse patient outcomes.

bioRxiv · Nov 28, 2019 · PreprintCancer Biology

LINE-1 ORF2P EXPRESSION IS NEARLY IMPERCEPTIBLE IN HUMAN CANCERS

D. Ardeljan, X. Wang, M. Oghbaie, M. S. Taylor, D. Husband, V. Deshpande, J. P. Steranka, M. Gorbounov, W. R. Yang, B. Sie, H. B. Larman, H. Jiang, K. R. Molloy, I. Altukhov, Z. Li, , J. LaCava

The paper reports that ORF2p expression is undetectable in human cancers despite high ORF1p expression and somatic L1 retrotransposition.

bioRxiv · Aug 22, 2019Cancer Biology

Entropic forces drive cellular contact guidance

G. Buskermolen, H. Suresh, S. Shishvan, A. Vigliotti, A. deSimone, N. Kurniawan, C. Bouten, V. Deshpande

The paper investigates contact guidance in cells by analyzing alignment on micropatterned substrates and identifies two regimes: one driven by biochemical changes and another by entropic forces.

bioRxiv · Nov 26, 2018Biophysics