N. Nguyen

Treponema pallidum periplasmic and membrane proteins are recognized by circulating and skin CD4+ T cells

The paper identifies Tp-specific CD4+ T cell responses in blood and skin of syphilis patients, showing persistence after treatment and highlighting potential vaccine targets.

Disrupting CD38-driven T cell dysfunction restores sensitivity to cancer immunotherapy

This study shows that targeting CD38 improves T cell function and restores response to immunotherapy in melanoma models.

Engineered Protein Nanosheets for the Scale up of Mesenchymal Stem Cell Culture on Bioemulsions

This paper develops engineered protein nanosheets to stabilize bioemulsions for scalable mesenchymal stem cell culture, showing 100-fold expansion and matrix deposition.

Lymph node fibroblast phenotypes and immune crosstalk regulated by Podoplanin activity

This study shows that Podoplanin deletion in fibroblastic reticular cells increases inflammatory signaling and disrupts stromal-immune crosstalk in lymph nodes.

Emergent remote stress-focusing drive submucosal collagen fiber remodeling in intestinal anastomotic surgery

This study identifies remote stress-focusing regions in intestinal anastomoses using geometric analysis, FEM, and in-vivo experiments, showing collagen fiber re-orientation correlates with stress distribution.

EGFR-initiated endocytosis of Wnt9a and Fzd9b is required for β-catenin signaling

The paper shows that EGFR-mediated endocytosis of Wnt9a and Fzd9b is necessary for β-catenin signaling.

The Geometric Evolution of Aortic Dissections: Predicting Surgical Success using Fluctuations in Integrated Gaussian Curvature

This paper introduces a geometric descriptor based on integrated Gaussian curvature to predict surgical success in aortic dissections by analyzing shape changes.

Antibody evasion by SARS-CoV-2 Omicron subvariants BA.2.12.1, BA.4, and BA.5

This study analyzes antibody evasion by SARS-CoV-2 Omicron subvariants BA.2.12.1, BA.4, and BA.5, finding BA.4/5 shows greater resistance to neutralizing antibodies than BA.2.12.1.

Analysis of the leaf metabolome in Arabidopsis thaliana mutation accumulation lines reveals association of pleiotropy and fitness consequences

The paper analyzes the metabolome of Arabidopsis thaliana mutation accumulation lines to show that high fitness mutations are less disruptive to cellular physiology and more associated with transcription regulator genes.

Gastrointestinal Helminths Increase Bordetella bronchiseptica Shedding and Host Variation in Supershedding

This study shows that gastrointestinal helminths increase Bordetella bronchiseptica shedding and host variation in supershedding through immune system interactions.

Novel Cluster AZ Arthrobacter phages Powerpuff, Lego, and YesChef exhibit close functional relationships with Microbacterium phages

This study identifies three novel Arthrobacter phages that show close functional relationships with Microbacterium phages, highlighting the need for multiple metrics to assess phage relatedness.

Distinct clonal evolution of B-cells in HIV controllers with neutralizing antibody breadth

The paper analyzes B-cell receptor repertoires in HIV controllers to identify clonal evolution and somatic hypermutation associated with neutralizing antibody breadth.

ISG15 drives immune pathology and respiratory failure during viral infection

This study shows that lack of deISGylation during viral infection leads to immune pathology and respiratory failure, with extracellular ISG15 playing a key role in inflammation and disease severity.

Analysis of biosynthesis and composition of cuticular wax in wild type bilberry (Vaccinium myrtillus L.) and its glossy mutant

The paper compares cuticular wax biosynthesis, composition, and gene expression between wild type and glossy mutant bilberry fruits, finding differences in compound proportions and morphology.

Traceback of Core Transcription Factors for Soybean Root Growth Maintenance under Water Deficit

The paper identifies core transcription factors regulating root growth in soybean under water deficit by integrating phylogenetic analysis and transcriptome data.

Frequent extrachromosomal oncogene amplification drives aggressive tumors

This study shows that extrachromosomal DNA amplification of oncogenes is common in human cancers and is associated with worse patient outcomes.

Incipient local adaptation in a fungus: evolution of heavy metal tolerance through allelic and copy-number variation

This study identifies allelic and copy-number variation in Suillus luteus linked to heavy metal tolerance in response to soil contamination.

An activity-guided map of electrophile-cysteine interactions in primary human immune cells

The paper maps electrophile-sensitive cysteines in primary human T cells and shows how electrophilic compounds affect T cell activation through cysteine modification.

Tetraploidy in rodent cardiac stem cells confers enhanced biological properties

The paper compares ploidy in cardiac interstitial cells between rodents and large mammals, finding species-specific differences in tetraploidy and its functional implications.

A human ex vivo dengue virus neutralization assay identifies priority antibodies and epitopes for vaccines and therapeutics.

This study develops an ex vivo dengue virus neutralization assay using mosquitoes to identify potent human monoclonal antibodies and their epitopes for vaccine and therapeutic development.

A novel virulence phenotype rapidly assesses Candida fungal pathogenesis in healthy and immunocompromised Caenorhabditis elegans hosts

This study introduces a lineage growth assay to assess fungal virulence in C. elegans, showing differences in host fitness between healthy and immunocompromised hosts infected with Candida species.