K. Turner

Breakage fusion bridge cycles drive high oncogene copy number, but not intratumoral genetic heterogeneity or rapid cancer genome change

The paper introduces OM2BFB, an algorithm detecting BFB amplifications using OGMs, showing high precision and recall, and finds BFB events are common in certain cancers but not linked to intratumoral heterogeneity or rapid genome change.

Evolution of gene expression across brain regions in behaviorally divergent deer mice

This study examines gene expression differences across brain regions in two deer mouse species and their hybrids, finding widespread interspecific variation and regional modularity in gene regulation.

Collateral sensitivity increases the efficacy of a rationally designed bacteriophage combination to control Salmonella enterica

This study identifies host susceptibility and resistance factors for Salmonella enterica infected by bacteriophages SPLA1a and SPLA5b, showing that their combination reduces phage resistance emergence.

Components of Isolated Skeletal Muscle Differentiated Through Antibody Validation

The paper describes a method to isolate skeletal muscle from mice, generate satellite cells for culture, and validate cell populations using immunofluorescence.

Optimizing In Situ Proximity Ligation Assays for Mitochondria, ER, or MERC Markers in Skeletal Muscle Tissue and Cells

This paper describes a protocol for using proximity ligation assays (PLA) to study protein-protein interactions in mitochondria-endoplasmic reticulum contact sites (MERCs) in mouse skeletal muscle tissue and cells.

Creating Optimal Conditions for OPA1 isoforms by Western Blot in Muscle Tissue

This paper presents an optimized western blot protocol to isolate and detect five OPA1 isoforms in muscle tissue.

The Evolution of Centriole Degradation in Mouse Sperm

This paper investigates how sperm centrioles evolved to become dispensable in mice by analyzing changes in the FAM161A protein and centriole structure across rodent species.

Effects of genomic and functional diversity on stand-level productivity and performance of non-native Arabidopsis

The paper tests how genetic diversity in Arabidopsis thaliana affects stand-level productivity and performance in its colonized range, finding no link to biomass but increased fecundity under high resource conditions.

Frequent extrachromosomal oncogene amplification drives aggressive tumors

This study shows that extrachromosomal DNA amplification of oncogenes is common in human cancers and is associated with worse patient outcomes.

A new massively-parallel transposon mutagenesis approach comparing multiple datasets identifies novel mechanisms of action and resistance to triclosan

This paper introduces a new TraDIS approach with AlbaTraDIS tool to analyze triclosan resistance mechanisms across multiple concentrations, identifying novel genes involved in bacterial survival.

Drought frequency predicts life history strategies in Heliophila

The paper examines how drought frequency influences life history strategies in Heliophila, finding that perennials thrive in less drought-prone environments while annuals escape drought during seed phases.

The essential genome of Escherichia coli K-12

This study benchmarks TraDIS against single gene deletion libraries to identify essential genes in E. coli, revealing new essential genes and correcting previous designations.