Borrowing Transcriptional Kinases to Activate Apoptosis
R. C. Sarott, S. P. Gourisankar, B. A. Karim, S. Nettles, H. Yang, B. Dwyer, J. M. Simanauskaite, J. Tse, H. Abuzaid, A. Krokhotin, T. Zhang, S. M. Hinshaw, M. R. Green, G. R. Crabtree, N. Gray
The paper develops bivalent molecules that convert kinase inhibitors into activators of proapoptotic genes, achieving selective killing of DLBCL cells with low cytotoxicity.
bioRxiv · Oct 23, 2023 · PreprintCancer Biology