M. R. Green

Borrowing Transcriptional Kinases to Activate Apoptosis

The paper develops bivalent molecules that convert kinase inhibitors into activators of proapoptotic genes, achieving selective killing of DLBCL cells with low cytotoxicity.

Inhibiting the GPI Transamidase Subunit GPAA1 Abolishes CD24 Surface Localization and Enhances Macrophage-Mediated Phagocytosis of Ovarian Cancer Cells

This study identifies GPAA1 as a regulator of CD24 surface expression and shows that inhibiting GPAA1 enhances macrophage-mediated phagocytosis of ovarian cancer cells.

CREBBP lysine acetyltransferase domain mutations create zombie enzymes that alter chromatin loading dynamics and prevent EP300 redundancy

The paper shows that CREBBP mutations disrupt chromatin loading dynamics and EP300 redundancy, creating zombie enzymes that impair enhancer activation in GC B-cells and lymphoma.

CD8 T-cell dysfunction is linked with CAR T-cell failure and can be mitigated by a non-alpha IL-2 agonist, pegenzileukin

The paper identifies dysfunctional CD8 CAR T-cells in rrLBCL tumors and shows that pegenzileukin mitigates this dysfunction, improving CAR T-cell responses.

Immune microenvironment subtypes and association with tumor cell mutations and antigen expression in follicular lymphoma.

The paper identifies immune microenvironment subtypes in follicular lymphoma linked to tumor mutations and antigen expression, informing potential immunotherapeutic strategies.

Single-cell Characterization of Acute Myeloid Leukemia and its Microenvironment Following PD-1 Blockade Based Therapy

This study analyzes single-cell RNA and TCR profiles from AML patients before and after PD-1 blockade therapy to identify factors influencing response and resistance.

E3 Ligase UBR5 HECT domain mutations in lymphoma control maturation of B cells via alternative splicing

This study shows that UBR5 HECT domain mutations in lymphoma disrupt B cell maturation by altering alternative splicing, suggesting a role in mantle cell lymphoma initiation.