Author

S. Nijjar

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:cell signaling & trafficking· 1 Assay:electrophysiology· 1 Organism:human· 1 Research Focus:protein folding & dynamics· 1 Assay:structural biology· 1

Frequent Co-Authors

N. Dale· 2 shared A. D. Cameron· 1 shared C. G. Savva· 1 shared D. H. Brotherton· 1 shared D. Maddison· 1 shared E. de Wolf· 1 shared L. Meigh· 1 shared M. J. Cann· 1 shared

Activity by Year

2020-2024 · peak 1/yr

Co-Author Collaboration Network

9 top collaborators · 21 mutual co-author links

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2 shared papersBiochemistry

N. Dale

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2 papers

Recent·Most cited

Structures of wild-type and a constitutively closed mutant of connexin26 shed light on channel regulation by CO2

D. H. Brotherton, S. Nijjar, C. G. Savva, N. Dale, A. D. Cameron

The paper shows that mutating K125 in Cx26 to glutamate mimics CO2 regulation, causing gap junctions to remain closed, and reveals structural changes in Cx26 that explain this regulation.

eLife · Jun 3, 2024Peer-reviewedBiochemistry

Opposing modulation of Cx26 gap junctions and hemichannels by CO2

S. Nijjar, D. Maddison, L. Meigh, E. de Wolf, T. Rodgers, M. J. Cann, N. Dale

This study shows that CO2 modulates Cx26 gap junctions and hemichannels oppositely through carbamylation, with specific residues K125 and R104 involved.

bioRxiv · Jul 27, 2020Cell Biology