Author

A. D. Cameron

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 5 Plant Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Assay:structural biology· 4 Research Focus:cell type annotation· 2 Research Focus:protein folding & dynamics· 2 Research Focus:protein structure prediction· 2 Organism:Arabidopsis· 1 Research Focus:cell signaling & trafficking· 1 Assay:cryo-EM· 1

Frequent Co-Authors

D. H. Brotherton· 4 shared N. Dale· 2 shared A. M. E. Jones· 1 shared B. Byrne· 1 shared C. Cecchetti· 1 shared C. E. Hatton· 1 shared C. G. Savva· 1 shared C. S. Guy· 1 shared

Activity by Year

2019-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 10 mutual co-author links

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4 shared papersBiochemistry

D. H. Brotherton

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Author profile →

6 papers

Recent·Most cited

Structures of wild-type and a constitutively closed mutant of connexin26 shed light on channel regulation by CO2

D. H. Brotherton, S. Nijjar, C. G. Savva, N. Dale, A. D. Cameron

The paper shows that mutating K125 in Cx26 to glutamate mimics CO2 regulation, causing gap junctions to remain closed, and reveals structural changes in Cx26 that explain this regulation.

eLife · Jun 3, 2024Peer-reviewedBiochemistry

Mechanism of substrate binding and transport in BASS transporters

P. Becker, F. B. Naughton, D. H. Brotherton, R. Pacheco-Gomez, O. Beckstein, A. D. Cameron

This study determines the crystal structure of a BASS transporter in complex with pantoate, revealing how substrate binding is coupled to sodium ion binding and transport through conformational changes.

bioRxiv · Jun 2, 2023Biochemistry

Structure and mechanism of a cytosine transport protein

C. E. Hatton, D. H. Brotherton, A. D. Cameron

The paper solves the crystal structure of CodB, a cytosine transporter, and compares it to Mhp1 to elucidate substrate transport mechanisms in the NCS1 family.

bioRxiv · Dec 23, 2021 · PreprintBiochemistry

Structural and functional insights into the mechanism of action of plant boron transporters

S. Saouros, T. C. Mohan, C. Cecchetti, S. Lehmann, J. D. Barritt, N. J. Scull, P. Simpson, Y. Alguel, A. D. Cameron, A. M. E. Jones, B. Byrne

This study investigates the function of plant boron transporters by analyzing mutations in Arabidopsis and yeast, and provides structural insights into their mechanism.

bioRxiv · Dec 15, 2020 · PreprintPlant Biology

Conformational changes and channel gating induced by CO2 binding to Connexin26

D. H. Brotherton, C. Savva, T. Ragan, V. Linthwaite, M. Cann, N. Dale, A. D. Cameron

This study shows CO2 directly affects Connexin26 gap junctions by inducing conformational changes that regulate channel gating.

bioRxiv · Aug 11, 2020 · PreprintBiochemistry

Structural basis of glycerophosphodiester recognition by the Mycobacterium tuberculosis substrate-binding protein UgpB

J. Fenn, R. Nepravishta, C. S. Guy, J. Harrison, J. Angulo, A. D. Cameron, E. Fullam

This study determines the structure of Mtb UgpB bound to GPC and shows it recognizes other glycerophosphodiesters, enhancing understanding of nutrient scavenging in tuberculosis.

bioRxiv · Jan 28, 2019Biochemistry