Author

S. Nik-Zainal

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3

Signature Assays, Organisms & Methods

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Assay:DNA methylation· 2 Organism:human· 2 Approach:statistical model· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1

Frequent Co-Authors

H. Davies· 3 shared X. Zou· 2 shared A. B. Brinkman· 1 shared A. Brown· 1 shared A. Butler· 1 shared A. Degasperi· 1 shared A. Ferrari· 1 shared A. Husain· 1 shared

Activity by Year

2018-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 23 mutual co-author links

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3 shared papersCancer Biology

H. Davies

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3 papers

Recent·Most cited

A living biobank of canine mammary tumor organoids as a comparative model for human breast cancer

M. Inglebert, M. Dettwiler, K. Hahn, A. Letko, C. Droegemueller, J. G. Doench, A. Brown, Y. Memari, H. Davies, A. Degasperi, S. Nik-Zainal, S. Rottenberg

This study establishes a canine mammary tumor organoid biobank to model human breast cancer, showing genetic and phenotypic conservation and utility for drug testing and CRISPR screening.

bioRxiv · Sep 2, 2022Cancer Biology

Epigenetic dysregulation underpins tumorigenesis in a cutaneous tumor syndrome.

H. Davies, K. Hodgson, E. Schwalbe, J. Coxhead, N. Sinclair, X. Zou, S. Cockell, A. Husain, S. Nik-Zainal, N. Rajan

The paper identifies epigenetic mutations as drivers of tumorigenesis in CYLD cutaneous syndrome, revealing intra-tumor heterogeneity and metastatic potential.

bioRxiv · Jul 1, 2019 · PreprintCancer Biology

Partially methylated domains are hypervariable in breast cancer and fuel widespread CpG island hypermethylation

A. B. Brinkman, S. Nik-Zainal, F. Simmer, F. G. Rodriguez-Gonzalez, M. Smid, L. B. Alexandrov, A. Butler, S. Martin, H. Davies, G. Dominik, X. Zou, M. Ramakrishna, J. Staaf, M. Ringner, A. Sieuwerts, , H. G. Stunnenberg

The paper shows PMDs are hypervariable in breast cancer and drive CGI hypermethylation, but do not significantly repress cancer genes.

bioRxiv · Nov 15, 2018Cancer Biology