A Cyclic Phosphoramidate Prodrug of 2-deoxy-2-fluoro-2-C-methylguanosine for the Treatment of Dengue Infection
R. Karuna, F. Yokokawa, K. Wang, J. Zhang, H. Xu, G. Wang, M. Ding, W. L. Chan, N. Abdul Ghafar, A. Leonardi, C. C. Seh, P. G. Seah, W. Liu, S. P. S. Rao, S. P. Lim, , Y.-L. Chen
This paper identifies a cyclic phosphoramidate prodrug that shows anti-dengue activity in vitro and in vivo but is suspended due to toxicity concerns.
Antimicrobial Agents and Chemotherapy · Nov 17, 2020Peer-reviewedMicrobiology