Y.-L. Chen

Clostridium innocuum, an opportunistic gut pathogen, inactivates host gut progesterone and arrests ovarian follicular development

This study identifies Clostridium innocuum as a gut bacterium that inactivates progesterone by converting it to epipregnanolone, leading to decreased serum progesterone and follicular arrest in mice.

Single extracellular vesicle imaging and computational analysis identifiesinherent architectural heterogeneity

The paper uses cryo-TEM and a segmentation model to analyze EV architecture, finding consistent structural heterogeneity across different sources and purification methods.

OsUVR8b, rather than OsUVR8a, plays a predominant role in rice UVR8-mediated UV-B response.

This study identifies OsUVR8b as the primary mediator of UV-B response in rice, showing it has a stronger role than OsUVR8a in growth inhibition and gene regulation under UV-B exposure.

MiR-221/222-enriched ADSC-exosome mitigates PM exposure-exacerbated cardiac ischemia/reperfusion injury through the modulation of the BNIP3/LC3B/PUMA pathway

This study shows that PM exposure worsens cardiac ischemia/reperfusion injury, which is mitigated by ADSC-exosome containing miR-221/222 through modulation of the BNIP3/LC3B/PUMA pathway.

An acidophilic fungus is integral to prey digestion in a carnivorous plant

This study identifies an acidophilic fungus as a key player in prey digestion by a carnivorous plant, showing gene co-option and synergistic effects in digestion.

Purinergic P2Y2 Receptor-Induced Activation of Endothelial TRPV4 Channels Mediates Lung Ischemia-Reperfusion Injury

This study identifies the purinergic P2Y2 receptor as a mediator of lung ischemia-reperfusion injury by activating endothelial TRPV4 channels through extracellular ATP release via Panx1.

Muscle FOXO-specific overexpression and endurance exercise protects skeletal muscle and heart from defects caused by a high-fat diet in young Drosophila

This study shows that muscle FOXO overexpression and endurance exercise protect skeletal and heart muscle from high-fat diet-induced defects in Drosophila by enhancing antioxidant pathways and lipid catabolism.

Circulating androgen regulation by androgen-catabolizing gut bacteria in male mouse gut

This study shows that oral administration of Thauera sp. strain GDN1 reduces serum androgen levels in male mice by catabolizing androgens in the gut.

CspZ FH-binding sites as epitopes promote antibody-mediated Lyme borreliae clearance

The paper shows that antibodies targeting CspZ FH-binding sites effectively clear Lyme borreliae in vitro and in vivo, highlighting their importance for vaccine development.

De-novo generation of novel phenotypically active molecules for Chagas disease from biological signatures using AI-driven generative chemistry

This paper uses AI-driven generative chemistry to design a novel molecule active against Chagas disease parasites, validated experimentally.

Identification of essential β-oxidation genes and corresponding metabolites for estrogen degradation by actinobacteria

This study identifies essential β-oxidation genes and metabolites involved in estrogen degradation by actinobacteria using transcriptomics, gene disruption, and metabolite profiling.

Integrated multi-omics investigations reveal the key role of synergistic microbial networks in removing plasticizer di-(2-ethylhexyl) phthalate from estuarine sediments

This study identifies synergistic microbial networks in estuarine sediments that degrade DEHP, with Acidovorax and Sedimenticola as key degraders and horizontal gene transfer playing a role in DEHP degradation capacity.

A Cyclic Phosphoramidate Prodrug of 2-deoxy-2-fluoro-2-C-methylguanosine for the Treatment of Dengue Infection

This paper identifies a cyclic phosphoramidate prodrug that shows anti-dengue activity in vitro and in vivo but is suspended due to toxicity concerns.

Genetic and metabolite biomarkers reveal actinobacteria-mediated estrogen biodegradation in urban estuarine sediment

This study identifies actinobacterial genes and metabolites involved in estrogen degradation in urban estuarine sediments and finds actinobacteria, not proteobacteria, are primarily responsible for estrogen breakdown.

Broad and strong memory CD4+ and CD8+ T cells induced by SARS-CoV-2 in UK convalescent COVID-19 patients.

This study examines T cell immunity in UK COVID-19 patients, finding stronger and broader memory T cell responses in severe cases, with implications for vaccine design.

The Angiosarcoma Project: enabling genomic and clinical discoveries in a rare cancer through patient-partnered research

The paper describes the Angiosarcoma Project, a patient-partnered initiative that generates genomic data on angiosarcoma, identifying recurrent mutations and potential therapeutic targets.

Retroconversion of estrogens into androgens by bacteria via a cobalamin-mediated methylation

The paper identifies a bacterial strain capable of converting estrogens into androgens via cobalamin-mediated methylation, revealing a novel metabolic pathway.

Genome analysis of the steroid-degrading denitrifying Denitratisoma oestradiolicum DSM 16959 and Denitratisoma sp. strain DHT3

The paper presents the genomes of two anaerobic estrogen-degrading bacteria and identifies genes involved in their steroid degradation pathways.