Author

S. P. S. Rao

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 2 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 2 Approach:deep learning· 1 Research Focus:drug response / drug discovery· 1 Organism:human· 1 Organism:mouse· 1 Organism:rat· 1

Frequent Co-Authors

S. Williams· 2 shared Y.-L. Chen· 2 shared A. J. M. Wollman· 1 shared A. Leonardi· 1 shared A. W. Guiguemde· 1 shared C. Bower-Lepts· 1 shared C. C. Seh· 1 shared D. Paape· 1 shared

Activity by Year

2019-2021 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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2 shared papersPharmacology & Toxicology

S. Williams

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Author profile →

3 papers

Recent·Most cited

Pharmacology & ToxicologybioRxivPreprintDec 10, 2021

De-novo generation of novel phenotypically active molecules for Chagas disease from biological signatures using AI-driven generative chemistry

M. Pikusa, O. Rene, S. Williams…·F. Nigsch

This paper uses AI-driven generative chemistry to design a novel molecule active against Chagas disease parasites, validated experimentally.

DOI 10.1101/2021.12.10.472084

deep learningdrug response / drug discovery

𝕏 PostBluesky

MicrobiologyAntimicrobial Agents and ChemotherapyPeer-reviewedNov 17, 2020

A Cyclic Phosphoramidate Prodrug of 2-deoxy-2-fluoro-2-C-methylguanosine for the Treatment of Dengue Infection

R. Karuna, F. Yokokawa, K. Wang…·Y.-L. Chen

This paper identifies a cyclic phosphoramidate prodrug that shows anti-dengue activity in vitro and in vivo but is suspended due to toxicity concerns.

DOI 10.1128/aac.00654-20

𝕏 PostBluesky

MicrobiologybioRxivApr 24, 2019

Targeting the trypanosome kinetochore with CLK1 protein kinase inhibitors

M. Saldivia, S. P. S. Rao, E. Fang…·J. C. Mottram

This study identifies CLK1 as a novel drug target in Trypanosoma brucei by showing its essential role in kinetochore function and cell survival through kinase inhibition.

DOI 10.1038/s41564-020-0745-6

humanexperimental assay

𝕏 PostBluesky