S. Pigolotti

Blocking uncertain mispriming errors of PCR

This paper demonstrates that a mixture of multiple blocker sequences can suppress PCR errors even with partial contaminating sequence information, improving the fidelity of PCR and related techniques.

Genome replication in asynchronously growing microbial populations

The paper predicts DNA fragment abundance in asynchronously growing cultures using stochastic models of DNA replication programs and validates these predictions against experimental data in E. coli and budding yeast.

Error-suppression mechanism of PCR by blocker strands

This study investigates how blocker strands suppress PCR errors by combining experiments and modeling, showing they destabilize mishybridized complexes and create kinetic barriers.

Speed fluctuations of bacterial replisomes

This study infers bacterial replisome dynamics from DNA abundance distributions and finds speed increases with temperature and genome-wide speed variations correlated with mutation rates.

Generalized Euler-Lotka equation for correlated cell divisions

The paper derives a generalized Euler-Lotka equation for microbial populations with correlated cell divisions and shows the discrepancy with the classical equation is measurable.

Bifractal nature of chromosome contact maps

This paper analyzes Hi-C contact maps using multifractal analysis, revealing bifractal properties and detecting conformational changes in human stem cell differentiation.

Ocean currents promote rare species diversity in protists

The paper shows ocean currents increase rare protist diversity by analyzing metagenomic data and a coalescence model.

Error-speed correlations in biopolymer synthesis

This study shows that error and speed in biopolymer synthesis are correlated, with enzyme error-correction mechanisms determining whether faster synthesis leads to better or worse errors.

Bet-hedging strategies in expanding populations

This paper develops a theory of bet-hedging for expanding populations in fluctuating environments, finding it more advantageous in spatially fluctuating environments and at slow variation rates.